Supplement Wise

Evidence Database

Every ingredient claim we score, graded A–F on the strength of the peer-reviewed research behind it. Search, filter and jump to the studies.

514 ingredients39 graded claims500 cited studies

My saved evidence

Search claims or studies

Claim grade

Category

Species studied

Study type

Evidence strength

Confidence

Grades reflect the weight of the published evidence in dogs, not marketing. A = multiple high-quality canine trials · B = solid canine or strong extrapolated evidence · C = limited/mixed · D = mostly anecdotal · F = evidence against.

UNCLASSIFIED
100% Beef Collagen
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% Grass-Fed Beef Heart
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% grass-fed beef kidney
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% Grass-Fed Beef Liver
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% grass-fed beef pancreas
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% grass-fed beef spleen
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% grass-fed bone powder
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% Grass-Fed Lamb Liver
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% grass-fed, freeze-dried beef bones
low confidenceOverallUNKNOWN
UNCLASSIFIED
100% Pure Proprietary Blend Marine Phytoplankton
low confidenceOverallUNKNOWN
UNCLASSIFIED
13% Alcohol Base
low confidenceOverallUNKNOWN
UNCLASSIFIED
A proprietary blend containing extracts of
low confidenceOverallUNKNOWN
UNCLASSIFIED
A proprietary blend of
low confidenceOverallUNKNOWN
Ingredient
A Synergistic Postbiotic Blend of Yeast
Also: A Synergistic Postbiotic Blend of Yeast
low confidenceOverallUNKNOWN
UNCLASSIFIED
Aloe Vera 200:1
low confidenceOverallUNKNOWN
UNCLASSIFIED
Ancient Humic & Fulvic Acid
low confidenceOverallUNKNOWN
UNCLASSIFIED
Ascorbyl palmitate form of vitamin c
low confidenceOverallUNKNOWN
Ingredient
Avocado/Soybean Unsaponifiables (ASU) Powder
Also: Avocado/Soybean Unsaponifiables (ASU) Powder
low confidenceOverallUNKNOWN
UNCLASSIFIED
Bacillus coagulans, bacillus subtilis blend
low confidenceOverallUNKNOWN
probiotic
Bacillus licheniformis
low confidenceOverallUNKNOWN
UNCLASSIFIED
Beef Liver Glandular
low confidenceOverallUNKNOWN
HOMEOPATHIC
Berberis vulgaris (homeopathic)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Betaine hydrochloride
low confidenceOverallUNKNOWN
Ingredient
Bifdobacterium Infantis
Also: Bifdobacterium Infantis
low confidenceOverallUNKNOWN
Ingredient
Bifidobacterium Biﬁdum
Also: Bifidobacterium Biﬁdum
low confidenceOverallUNKNOWN
probiotic
Bifidobacterium infantis
low confidenceOverallUNKNOWN
Ingredient
bifidobacterium lungum subso. infantis
Also: bifidobacterium lungum subso. infantis
low confidenceOverallUNKNOWN
UNCLASSIFIED
Bromelain 2400 GDU
low confidenceOverallUNKNOWN
UNCLASSIFIED
Chlorella pyrenoidosa
low confidenceOverallUNKNOWN
Ingredient
citrus bioflavnoids
Also: citrus bioflavnoids
low confidenceOverallUNKNOWN
UNCLASSIFIED
Cranberry Fruit Powder
low confidenceOverallUNKNOWN
UNCLASSIFIED
Deglycyrrhizinated licorice root (DGL)
low confidenceOverallUNKNOWN
Ingredient
dried Aspergillus oryzae fermentation solubles
Also: dried Aspergillus oryzae fermentation solubles
low confidenceOverallUNKNOWN
Ingredient
Dried Rhizopus oryzae Fermentation Product
Also: Dried Rhizopus oryzae Fermentation Product
low confidenceOverallUNKNOWN
Ingredient
dried Rhizopus oryzae fermentation solubles
Also: dried Rhizopus oryzae fermentation solubles
low confidenceOverallUNKNOWN
Ingredient
Dried Trichoderma longibrachiatum Fermentation Product
Also: Dried Trichoderma longibrachiatum Fermentation Product
low confidenceOverallUNKNOWN
Ingredient
dried Trichoderma longibrachiatum fermentation solubles
Also: dried Trichoderma longibrachiatum fermentation solubles
low confidenceOverallUNKNOWN
HOMEOPATHIC
Echinacea (homeopathic)
low confidenceOverallUNKNOWN
BLEND
Enzyme and probiotic blend
low confidenceOverallUNKNOWN
Ingredient
EPAX® 4020 EE- High Omega 3 Concentrate Oil
Also: EPAX® 4020 EE- High Omega 3 Concentrate Oil
low confidenceOverallUNKNOWN
UNCLASSIFIED
ESM® eggshell membrane
low confidenceOverallUNKNOWN
excipient
Ethanol
low confidenceOverallUNKNOWN
Ingredient
Folic Adic
Also: Folic Adic
low confidenceOverallUNKNOWN
UNCLASSIFIED
FOS (fructooligosaccharides)
low confidenceOverallUNKNOWN
HOMEOPATHIC
Graphites (homeopathic)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Gut Guard
low confidenceOverallUNKNOWN
excipient
High-Oleic Sunflower Oil
low confidenceOverallUNKNOWN
UNCLASSIFIED
High-oleic sunflower oil a heart healthy carrier oil
low confidenceOverallUNKNOWN
UNCLASSIFIED
Homeopathic Aconite (200C)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Homeopathic Arnica
low confidenceOverallUNKNOWN
UNCLASSIFIED
Humic & Fulvic Acids
low confidenceOverallUNKNOWN
other
Humic and Fulvic Acids
low confidenceOverallUNKNOWN
homeopathic
Hydrangea arborescens
low confidenceOverallUNKNOWN
HOMEOPATHIC
Hydrangea arborescens (homeopathic)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Immunoglobulin A (IgA)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Immunoglobulin G (IgG)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Immunoglobulin M (IgM)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Invertase
low confidenceOverallUNKNOWN
Ingredient
kefir micro-organisms
Also: kefir micro-organisms
low confidenceOverallUNKNOWN
probiotic
Lacticaseibacillus paracasei
low confidenceOverallUNKNOWN
probiotic
Lactobacillus fermentum
low confidenceOverallUNKNOWN
Ingredient
Lactobacillus Plantrum
Also: Lactobacillus Plantrum
low confidenceOverallUNKNOWN
Ingredient
lactobacillus rhamosus
Also: lactobacillus rhamosus
low confidenceOverallUNKNOWN
Ingredient
Lactoperoxidase (from dried whey protein concentrate)
Also: Lactoperoxidase (from dried whey protein concentrate)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Liposomal quercetin
low confidenceOverallUNKNOWN
omega
Marine Algae Oil
low confidenceOverallUNKNOWN
Cited studies (2)
- Effects of dietary supplementation with algae, sunflower oil or soybean oil on folliculogenesis in the rabbit ovary during sexual maturation.Save — Acta histochemica (2020) · Journal Article
- Short communication: Diets supplemented with starch and corn oil, marine algae, or hydrogenated palm oil differently affect selected metabolite concentrations in cow and goat milk.Save — Journal of dairy science (2020) · Clinical Trial, Veterinary; Journal Article
UNCLASSIFIED
Marine algae oil Schizochytrium sp.
low confidenceOverallUNKNOWN
algae
Marine Phytoplankton
low confidenceOverallUNKNOWN
UNCLASSIFIED
Marshmallow root 4:1 extract
low confidenceOverallUNKNOWN
fatty acid
Medium Chain Triglycerides (MCT)
low confidenceOverallUNKNOWN
Ingredient
Microbuild®
Also: Microbuild®
low confidenceOverallUNKNOWN
UNCLASSIFIED
Mixed tocopherols antioxidant
low confidenceOverallUNKNOWN
UNCLASSIFIED
MRET (Molecular Resonance Effect Technology) activated deionized water
low confidenceOverallUNKNOWN
UNCLASSIFIED
Multi Strain Probiotic Blend
low confidenceOverallUNKNOWN
UNCLASSIFIED
Multi Strain Wolf Species Specific Patented Probiotics (15 Billion CFU/serving)Ancestral Lupine Probiotic Strains
low confidenceOverallUNKNOWN
UNCLASSIFIED
Multi-Strain Probiotic Blend Including Species-Specific Patented Probiotics
low confidenceOverallUNKNOWN
Ingredient
myHMB®
Also: myHMB®
low confidenceOverallUNKNOWN
UNCLASSIFIED
Nannochloropsis gaditana CCAP 849/5
low confidenceOverallUNKNOWN
UNCLASSIFIED
Non-GMO Sunflower Lecithin
low confidenceOverallUNKNOWN
UNCLASSIFIED
None
low confidenceOverallUNKNOWN
UNCLASSIFIED
Not less than 3 mg of each ingredient
low confidenceOverallUNKNOWN
HOMEOPATHIC
Nux vomica (homeopathic)
low confidenceOverallUNKNOWN
Ingredient
Oregon Grape Root
Also: Oregon Grape Root
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organ Care
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic alfalfa juice
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic aloe vera leaf powder
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Berberis vulgaris (Barberry)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic broccoli sprout powder
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic broccoli sprouts
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic burdock root
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic cat's claw
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic chaga mushroom extract
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic chamomile powder
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Chelidonium majus (Greater celandine)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Chinese skullcap
low confidenceOverallUNKNOWN
Ingredient
Organic Coriolus (Trametes versicolor)
Also: Organic Coriolus (Trametes versicolor)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic dandelion root
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Ethanol
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic fermented grasses
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic ginger root
low confidenceOverallUNKNOWN
Ingredient
Organic golden beets
Also: Organic golden beets
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic inulin from Jerusalem artichoke
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic inulin from organic Jerusalem artichoke
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Irish moss
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic lion's mane mushroom extract
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic maitake mushroom extract
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic marshmallow root
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic MCT powder (C8 & C10)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic mushrooms
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic nettle
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic oregano leaf
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic phellinus mushroom extract
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic poria cocos mushroom extract
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic red & brown kelp
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic sea greens (spirulina, chlorella, dunaliella & kelp)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Taraxacum officinalis (Dandelion root)In
low confidenceOverallUNKNOWN
UNCLASSIFIED
Organic Vegetable Glycerin
low confidenceOverallUNKNOWN
enzyme
Pancreatin
low confidenceOverallUNKNOWN
UNCLASSIFIED
Papain 50 000 PU
low confidenceOverallUNKNOWN
Ingredient
Porcine Cartilage
Also: Porcine Cartilage
low confidenceOverallUNKNOWN
Cited studies (3)
- Large Animal Models for Osteochondral Regeneration.Save — Advances in experimental medicine and biology (2018) · Journal Article; Review
- Metabolic disease in animals.Save — Seminars in musculoskeletal radiology (2002) · Journal Article; Review
- Autologous resurfacing.Save — Microscopy research and technique (2015) · Journal Article
HOMEOPATHIC
Porcine cartilage (homeopathic)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Porcine Pancreatin 8X
low confidenceOverallUNKNOWN
Ingredient
Powdered Green Lipped Sea Mussels
Also: Powdered Green Lipped Sea Mussels
low confidenceOverallUNKNOWN
UNCLASSIFIED
Prebiotic Chlorella spp
low confidenceOverallUNKNOWN
UNCLASSIFIED
Prepared in a 13% Alcohol Base
low confidenceOverallUNKNOWN
UNCLASSIFIED
Probiotic Species
low confidenceOverallUNKNOWN
UNCLASSIFIED
Probiotics Derived From Primordial Organic Soils
low confidenceOverallUNKNOWN
Ingredient
Proprietary Hip & Joint Blend
Also: Proprietary Hip & Joint Blend
low confidenceOverallUNKNOWN
UNCLASSIFIED
Purified Water
low confidenceOverallUNKNOWN
active
Qrill™Pet
low confidenceOverallUNKNOWN
UNCLASSIFIED
rBGH-free colostrum supplement for dogs
low confidenceOverallUNKNOWN
Ingredient
Reblancer
Also: Reblancer
low confidenceOverallUNKNOWN
Ingredient
Salmon Protein Hydrolyzed Condensed
Also: Salmon Protein Hydrolyzed Condensed
low confidenceOverallUNKNOWN
Ingredient
Sardine and Anchovies wild
Also: Sardine and Anchovies wild
low confidenceOverallUNKNOWN
UNCLASSIFIED
Serum-derived Immunoglobulin Concentrate (SBI)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Silicea (30C)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Slippery Elm Bark 4:1 extract
low confidenceOverallUNKNOWN
HOMEOPATHIC
Sulphur (homeopathic)
low confidenceOverallUNKNOWN
botanical
Taraxacum officinale
low confidenceOverallUNKNOWN
UNCLASSIFIED
Tetraselmis chui CCAP 8/6
low confidenceOverallUNKNOWN
Ingredient
Thiosinaminum
Also: Thiosinaminum
low confidenceOverallUNKNOWN
HOMEOPATHIC
Thiosinaminum (homeopathic)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Thuja Occidentalis (12C)
low confidenceOverallUNKNOWN
UNCLASSIFIED
Triple Extracted and Ethically Wildcrafted Turkey Tail Mushrooms
low confidenceOverallUNKNOWN
UNCLASSIFIED
Triple Extracted Ethically Wildcrafted Turkey Tail Mushrooms
low confidenceOverallUNKNOWN
Ingredient
Tynagen™
Also: Tynagen™
low confidenceOverallUNKNOWN
UNCLASSIFIED
Uva Ursi Powder
low confidenceOverallUNKNOWN
excipient
Vegetable Glycerin
low confidenceOverallUNKNOWN
UNCLASSIFIED
Vegetable Non-GMO Glycerin
low confidenceOverallUNKNOWN
UNCLASSIFIED
Witch Hazel
low confidenceOverallUNKNOWN
UNCLASSIFIED
Yeast Guard
low confidenceOverallUNKNOWN
Ingredient
Yeasty Beast I
Also: Yeasty Beast I
low confidenceOverallUNKNOWN
omega
Anchovy & Sardine Oil
low confidenceOverallA
Compare Claim Grade
Lower oxidation risk than large-fish oil
Short-lived species carry less heavy-metal load and typically fresher on shelf.
View studies & products →
ASave
Cited studies (1)
- Heavy metal contamination of commercial fish oils by fish species Save — Food Chemistry (2011) · analytical
antioxidant
Astaxanthin
medium confidenceOverallA
Cited studies (3)
- Effects of postexercise feeding of a supplemental carbohydrate and protein bar with or without astaxanthin from Haematococcus pluvialis to exercise-conditioned dogs.Save — American journal of veterinary research (2015) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Astaxanthin uptake in domestic dogs and cats.Save — Nutrition & metabolism (2010) · Journal Article
- Effects of astaxanthin supplementation in healthy and obese dogs.Save — Veterinary medicine (Auckland, N.Z.) (2019) · Journal Article
probiotic
Bacillus coagulans
medium confidenceOverallA
Cited studies (3)
- Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs.Save — Veterinary medicine and science (2024) · Journal Article
- Complete genome sequence of Bacillus coagulans CACC834 isolated from canine.Save — Journal of animal science and technology (2021) · Journal Article
- Effects of Bacillus coagulans (GBI-30, 6086) supplementation on apparent total tract nutrient digestibility and the fecal characteristics and metabolites, immunity, and microbiota of healthy adult dogs.Save — Journal of animal science (2025) · Journal Article; Randomized Controlled Trial, Veterinary
botanical
Boswellia serrata
Also: Boswellia
medium confidenceOverallA
Compare Claim Grade
Reduces OA signs in dogs
Old open-label canine study showed benefit; better human evidence in OA.
View studies & products →
CSave
Cited studies (4)
- Boswellic acid extract in dogs with chronic joint disease Save — Schweizer Archiv für Tierheilkunde (2004) · open-label
- Effects of a feed supplement, containing undenatured type II collagen (UC II®) and Boswellia Serrata, in the management of mild/moderate mobility disorders in dogs: A randomized, double-blind, placebo controlled, cross-over study.Save — PloS one (2024) · Journal Article; Randomized Controlled Trial, Veterinary
- Safety and efficacy of a feed additive consisting of an extract of olibanum from Boswellia serrata Roxb. ex Colebr. for use in dogs and horses (FEFANA asbl).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
- Measurement of 3-acetyl-11-keto-beta-boswellic acid and 11-keto-beta-boswellic acid in Boswellia serrata Supplements Administered to Dogs.Save — BMC veterinary research (2019) · Journal Article
UNCLASSIFIED
Calendula
high confidenceOverallA
Cited studies (3)
- Medicinal plant treatments for fleas and ear problems of cats and dogs in British Columbia, Canada.Save — Parasitology research (2008) · Journal Article; Research Support, Non-U.S. Gov't
- Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review.Save — BMC veterinary research (2019) · Journal Article; Systematic Review
- Comparative Efficacy of a Novel Topical Formulation with Antimicrobial Peptides and Encapsulated Plant Extracts Versus Conventional Therapies for Canine Otitis Externa.Save — Pathogens (Basel, Switzerland) (2025) · Comparative Study; Journal Article; Randomized Controlled Trial, Veterinary
botanical
Cranberry Extract
Also: Vaccinium macrocarpon
medium confidenceOverallA
Compare Claim Grade
Reduces recurrent bacterial UTI risk
Some evidence via anti-adhesion; not a treatment for active UTI.
View studies & products →
CSave
Cited studies (5)
- Cranberry extract prevents E. coli adhesion to canine uroepithelium Save — Research in Veterinary Science (2016) · in vitro
- Effects of cranberry extract on prevention of urinary tract infection in dogs and on adhesion of Escherichia coli to Madin-Darby canine kidney cellsSave — American Journal of Veterinary Research (2016) · CLINICAL_TRIAL
- Adherence of Uropathogenic Escherichia Coli in Dog Urine After Consumption of Food Supplemented with Cranberry (Vaccinium Macrocarpon).Save — Journal of veterinary research (2023) · Journal Article
- Safety and efficacy of a feed additive consisting of a proanthocyanidin-rich dry extract from the fruit of Vaccinium macrocarpon Aiton (cranberry extract) for dogs and cats (ACEL pharma S.r.l.).Save — EFSA journal. European Food Safety Authority (2026) · Journal Article
- Effects of cranberry extract on prevention of urinary tract infection in dogs and on adhesion of Escherichia coli to Madin-Darby canine kidney cells.Save — American journal of veterinary research (2016) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
omega
DHA
Also: Docosahexaenoic acid
medium confidenceOverallA
Compare Claim Grade
Neurologic and retinal development in puppies
Diets enriched with DHA improve trainability and visual acuity in puppies.
View studies & products →
ASave
Cited studies (4)
- Docosahexaenoic acid–enriched formula and puppy trainability Save — Journal of Animal Physiology and Animal Nutrition (2012) · RCT
- Control of adrenal androgen production.Save — Endocrine research (1984) · Journal Article; Review
- Sphingolipids and DHA Improve Cognitive Deficits in Aged Beagle Dogs.Save — Frontiers in veterinary science (2022) · Journal Article
- Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals.Save — Nutrition research reviews (2025) · Journal Article; Review
Ingredient
EPAX® 4020 EE- High Omega-3 Concentrate Oil
Also: EPAX® 4020 EE- High Omega-3 Concentrate Oil
low confidenceOverallA
Randomized canine trials support EPA and DHA for osteoarthritis. Credit depends on the actual disclosed EPA+DHA dose, not merely total oil weight.

Compare	Claim	Grade
	Lower oxidation risk than large-fish oil Short-lived species carry less heavy-metal load and typically fresher on shelf. View studies & products →	ASave

Compare	Claim	Grade
	Reduces OA signs in dogs Old open-label canine study showed benefit; better human evidence in OA. View studies & products →	CSave

Compare	Claim	Grade
	Reduces recurrent bacterial UTI risk Some evidence via anti-adhesion; not a treatment for active UTI. View studies & products →	CSave

Compare	Claim	Grade
	Neurologic and retinal development in puppies Diets enriched with DHA improve trainability and visual acuity in puppies. View studies & products →	ASave

omega

Fish Oil (EPA/DHA)

high confidenceOverallA

Compare	Claim	Grade
	Reduces clinical signs of osteoarthritis in dogs Multiple randomised controlled trials show improved weight bearing, owner-assessed lameness and ability to rise at ~50–100 mg EPA+DHA / kg / day. View studies & products →	ASave
	Improves skin/coat and reduces pruritus in atopic dogs Consistent modest benefit as adjunctive therapy; effect size smaller than for OA. View studies & products →	BSave
	Slows cognitive decline in senior dogs Small canine studies suggestive; strongest evidence is from broader nutrient blends. View studies & products →	CSave

Cited studies (7)

Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogs Save — JAVMA (2010) · RCT
Effects of dietary fish oil on weight bearing in dogs with osteoarthritis Save — JAVMA (2010) · RCT
Multicenter veterinary practice assessment of the effects of omega-3 fatty acids on osteoarthritis in dogsSave — Journal of the American Veterinary Medical Association (2010) · RCT
A multicenter study of the effect of dietary supplementation with fish oil omega-3 fatty acids on carprofen dosage in dogs with osteoarthritisSave — Journal of the American Veterinary Medical Association (2010) · RCT
Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals.Save — Nutrition research reviews (2025) · Journal Article; Review

See all 7 studies →

Ingredient
Frankincense
Also: Frankincense
low confidenceOverallA
animal
Freeze-Dried Beef Pancreas
low confidenceOverallA
Canine veterinary references and clinical literature support pancreatic enzyme replacement for exocrine pancreatic insufficiency. Evidence does not establish a general health benefit for dogs without pancreatic enzyme deficiency.
Ingredient
Fructooligosaccharides
Also: Fructooligosaccharides
low confidenceOverallA
other
FruiteX-B (Calcium Fructoborate)
low confidenceOverallA
Human and preclinical evidence exists; direct canine clinical efficacy has not been established.
other
Glucosamine Sulfate
medium confidenceOverallA
Cited studies (3)
- A 2022 Systematic Review and Meta-Analysis of Enriched Therapeutic Diets and Nutraceuticals in Canine and Feline Osteoarthritis.Save — International journal of molecular sciences (2022) · Journal Article; Meta-Analysis; Systematic Review
- Corrigendum: Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: a prospective, block-randomized, double-blinded, placebo-controlled clinical trial.Save — Frontiers in veterinary science (2023) · Published Erratum
- Glycosylation in Canine Placentas.Save — Reproduction in domestic animals = Zuchthygiene (2024) · Journal Article
omega
Krill Oil
medium confidenceOverallA
Compare Claim Grade
Comparable OA benefit to fish oil per mg EPA+DHA
Small trials show similar outcomes; higher cost per mg omega-3 in Canada.
View studies & products →
BSave
Cited studies (1)
- Krill oil vs fish oil bioavailability in dogs Save — Lipids in Health and Disease (2019) · RCT
probiotic
Lactobacillus bulgaricus
medium confidenceOverallA
Cited studies (3)
- Safety and efficacy of a feed additive consisting of Enterococcus faecium NBIMCC 8270, Lactobacillus acidophilus NBIMCC 8242, Lactobacillus helveticus NBIMCC 8269, Lactobacillus delbrueckii ssp. lactis NBIMCC 8250, L. delbrueckii ssp. bulgaricus NBIMCC 8244 and Streptococcus thermophilus NBIMCC 8253 (Probiotic Lactina®) for cats and dogs (Lactina Ltd.).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
- Effects of a Lactobacillus fermentation product on the fecal characteristics, fecal microbial populations, immune function, and stress markers of adult dogs.Save — Journal of animal science (2023) · Randomized Controlled Trial, Veterinary; Journal Article
- [Standardization of the direct hemagglutination reaction induced by bacteria of the genus Lactobacillus].Save — Zhurnal mikrobiologii, epidemiologii i immunobiologii (1986) · English Abstract; Journal Article
probiotic
Lactobacillus paracasei
medium confidenceOverallA
Cited studies (3)
- Clinical effects of combined Lactobacillus paracasei and kestose on canine atopic dermatitis.Save — Polish journal of veterinary sciences (2023) · Journal Article
- Effects of live Bacillus pumilus SG154 or a Lacticaseibacillus paracasei 327 postbiotic on apparent total tract nutrient digestibility and the immune function and fecal characteristics, metabolites, and microbiota of healthy adult dogs.Save — Journal of animal science (2025) · Journal Article
- Effects of potential probiotics on the expression of cytokines and human β-defensins in human gingival epithelial cells and in vivo efficacy in a dog model.Save — Archives of oral biology (2022) · Journal Article; Randomized Controlled Trial
probiotic
Lactobacillus salivarius
medium confidenceOverallA
Cited studies (3)
- A multi-strain probiotic promoted recovery of puppies from gastroenteritis in a randomized, double-blind, placebo-controlled study.Save — The Canadian veterinary journal = La revue veterinaire canadienne (2023) · Randomized Controlled Trial, Veterinary; Journal Article
- Search of antimicrobial lactic acid bacteria from Salmonella-negative dogs.Save — BMC veterinary research (2022) · Journal Article
- In Vitro assessment of anti-Campylobacter activity of lactobacillus strains isolated from canine rectal swabs.Save — BMC veterinary research (2022) · Journal Article
UNCLASSIFIED
Limosilactobacillus Reuteri
medium confidenceOverallA
Cited studies (3)
- Potential Probiotic Properties and Complete Genome Analysis of Limosilactobacillus reuteri LRA7 from Dogs.Save — Microorganisms (2024) · Journal Article
- Effect of Limosilactobacillus reuteri ZJF036 on Growth Performance and Gut Microbiota in Juvenile Beagle Dogs.Save — Current microbiology (2023) · Journal Article; Randomized Controlled Trial, Veterinary
- Commensal Lactobacilli Enhance Sperm Qualitative Parameters in Dogs.Save — Frontiers in veterinary science (2022) · Journal Article
Ingredient
Methionine
Also: Methionine
low confidenceOverallA
Ingredient
Niacin Supplement
Also: Niacin Supplement
medium confidenceOverallA
Cited studies (3)
- Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC.Save — EFSA journal. European Food Safety Authority (2019) · Journal Article
- Preliminary study: voluntary food intake in dogs during tryptophan supplementation.Save — The British journal of nutrition (2011) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Tracheobronchial washings from seven vertebrate species as growth media for the four species of Bordetella.Save — FEMS immunology and medical microbiology (1994) · Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Omega-9 Fatty Acids
Also: Omega-9 Fatty Acids
low confidenceOverallA
UNCLASSIFIED
Organic chamomile
medium confidenceOverallA
Cited studies (1)
- Medicinal plants as therapeutic options for topical treatment in canine dermatology? A systematic review.Save — BMC veterinary research (2019) · Journal Article; Systematic Review
Ingredient
Potato
Also: Potato
medium confidenceOverallA
Cited studies (3)
- Diagnosis and management of food allergy and intolerance in dogs and cats.Save — Australian veterinary journal (1994) · Journal Article; Review
- Different carbohydrate sources in dog foods supported overall health and cardiac function: an 18-mo prospective study in healthy adult dogs.Save — Journal of animal science (2025) · Journal Article; Randomized Controlled Trial, Veterinary
- Isotianil (2(nd) edition) (Pesticides).Save — Food safety (Tokyo, Japan) (2023) · Journal Article
UNCLASSIFIED
Rosemary extractpreservative
medium confidenceOverallA
Cited studies (3)
- Epidemiological dynamics and spatial expansion of animals sporotrichosis in the Brazilian Amazon.Save — Comparative immunology, microbiology and infectious diseases (2026) · Journal Article
- Comparative Efficacy of a Novel Topical Formulation with Antimicrobial Peptides and Encapsulated Plant Extracts Versus Conventional Therapies for Canine Otitis Externa.Save — Pathogens (Basel, Switzerland) (2025) · Comparative Study; Journal Article; Randomized Controlled Trial, Veterinary
- Synergistic effect of essential oils and chlorhexidine against planktonic and biofilm-forming cells of Malassezia pachydermatis.Save — Veterinary and animal science (2024) · Journal Article
Ingredient
Selenium
Also: Selenium
medium confidenceOverallA
Cited studies (3)
- Selenium and Dogs: A Systematic Review.Save — Animals : an open access journal from MDPI (2021) · Journal Article; Review
- Leishmaniasis and Trace Element Alterations: a Systematic Review.Save — Biological trace element research (2021) · Journal Article; Systematic Review
- Prostaglandins and sleep.Save — Advances in neuroimmunology (1995) · Journal Article; Review
Ingredient
Silybin-phosphatidylcholine complex (SPC)
Also: Silybin-phosphatidylcholine complex (SPC)
low confidenceOverallA
Ingredient
Sodium Phosphate
Also: Sodium Phosphate
medium confidenceOverallA
Cited studies (3)
- Safety and efficacy of oral low-volume sodium phosphate bowel preparation for colonoscopy in dogs.Save — Journal of veterinary internal medicine (2008) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Acute hypernatremia and hypocalcemia after oral sodium phosphate administration to a dog.Save — Journal of veterinary internal medicine (2024) · Case Reports; Journal Article
- Pathological calcification in canine tendon-derived cells is modulated by extracellular ATP.Save — Veterinary research communications (2024) · Journal Article
Ingredient
Total Omega 3 Fatty Acids
Also: Total Omega 3 Fatty Acids
high confidenceOverallA
Cited studies (3)
- Effect of omega-3 fatty acids on canine atopic dermatitis.Save — The Journal of small animal practice (2004) · Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Supplementation with Silybum marianum Extract, Synbiotics, Omega-3 Fatty Acids, Vitamins, and Minerals: Impact on Biochemical Markers and Fecal Microbiome in Overweight Dogs.Save — Animals : an open access journal from MDPI (2024) · Journal Article
- Enhancing cognitive functions in aged dogs and cats: a systematic review of enriched diets and nutraceuticals.Save — GeroScience (2025) · Journal Article; Systematic Review; Research Support, Non-U.S. Gov't
Ingredient
Total Omega 6 Fatty Acids
Also: Total Omega 6 Fatty Acids
medium confidenceOverallA
Cited studies (2)
- Effect of omega-3 fatty acids on canine atopic dermatitis.Save — The Journal of small animal practice (2004) · Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Nutrient profile, amino acid digestibility, true metabolizable energy, and indispensable amino acid scoring of whole hemp seeds for use in canine and feline diets.Save — Journal of animal science (2023) · Journal Article
Ingredient
Total Polyunsaturated Fatty Acids
Also: Total Polyunsaturated Fatty Acids
medium confidenceOverallA
Cited studies (2)
- Evaluation of Soybean Ingredients in Pet Foods Applications: Systematic Review.Save — Animals : an open access journal from MDPI (2023) · Journal Article; Review
- Enhancing cognitive functions in aged dogs and cats: a systematic review of enriched diets and nutraceuticals.Save — GeroScience (2025) · Journal Article; Systematic Review; Research Support, Non-U.S. Gov't
Ingredient
UC-II® Collagen
Also: UC-II® Collagen
low confidenceOverallA
Ingredient
Vitamin A Supplement
Also: Vitamin A Supplement
medium confidenceOverallA
Cited studies (3)
- Stability of vitamin A at critical points in pet-feed manufacturing and during premix storage.Save — Frontiers in veterinary science (2024) · Journal Article
- Diet and skin disease in dogs and cats.Save — The Journal of nutrition (1998) · Journal Article; Review
- Safety evaluation of vitamin A in growing dogs.Save — The British journal of nutrition (2012) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Ingredient
Vitamin B12 Supplement
Also: Vitamin B12 Supplement
medium confidenceOverallA
Cited studies (3)
- The immunomodulatory effects of vitamins in cancer.Save — Frontiers in immunology (2024) · Journal Article; Review
- Gut Microbiome of Healthy and Arthritic Dogs.Save — Veterinary sciences (2020) · Journal Article
- Efficacy and tolerance of oral versus parenteral cyanocobalamin supplement in hypocobalaminaemic dogs with chronic enteropathy: a controlled randomised open-label trial.Save — The Journal of small animal practice (2024) · Journal Article; Randomized Controlled Trial, Veterinary; Research Support, Non-U.S. Gov't
vitamin
Vitamin D3
Also: Cholecalciferol
medium confidenceOverallA
Compare Claim Grade
Essential for bone, immune and cardiac health
Deficiency and excess both harmful; supplement only when a diet is measured-deficient.
View studies & products →
ASave
Cited studies (4)
- Serum 25(OH)D status and disease outcomes in dogs Save — Journal of Veterinary Internal Medicine (2018) · review
- Rickets, Vitamin D, and Ca/P Metabolism.Save — Hormone research in paediatrics (2022) · Journal Article; Review
- Hypercalcemia.Save — The Veterinary clinics of North America. Small animal practice (1989) · Journal Article; Review
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
Ingredient
Vitamin K1
Also: Vitamin K1
low confidenceOverallA
anti-inflammatory
Yucca Schidigera
low confidenceOverallA
Compare Claim Grade
Anti-inflammatory / odour-reduction claims
Mostly in-vitro and anecdotal; safety concerns at high doses.
View studies & products →
DSave
vitamin
B-Vitamin Complex
low confidenceOverallB
protein
Beef Collagen (Type I & II)
low confidenceOverallB
whole food
Broccoli Sprouts (Sulforaphane)
low confidenceOverallB
mineral
Chelated Mineral Premix
low confidenceOverallB
joint
Chondroitin Sulfate
Also: Chondroitin
high confidenceOverallB
Compare Claim Grade
Adds modest benefit when combined with glucosamine
Best evidence is combined formulations; monotherapy data are weaker.
View studies & products →
BSave
Cited studies (5)
- Chondroitin sulfate in canine OA — systematic review Save — Veterinary Anaesthesia and Analgesia (2018) · systematic review
- Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritisSave — The Veterinary Journal (2007) · RCT
- GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.Save — BioMed research international (2015) · Journal Article; Review
- Chondroitin sulfate proteoglycan-4: a biomarker and a potential immunotherapeutic target for canine malignant melanoma.Save — Veterinary journal (London, England : 1997) (2011) · Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Corrigendum: Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: a prospective, block-randomized, double-blinded, placebo-controlled clinical trial.Save — Frontiers in veterinary science (2023) · Published Erratum
homeopathic
Echinacea
medium confidenceOverallB
Cited studies (3)
- Evaluating the effect of oral administration of Echinacea hydroethanolic extract on the immune system in dog.Save — Autonomic & autacoid pharmacology (2015) · Journal Article
- Echinacea powder: treatment for canine chronic and seasonal upper respiratory tract infections.Save — Schweizer Archiv fur Tierheilkunde (2003) · Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
- Safety and efficacy of feed additives consisting of dried extracts from Echinacea angustifolia DC. or Echinacea purpurea (L.) Moench for use in cats and dogs (C.I.A.M.).Save — EFSA journal. European Food Safety Authority (2021) · Journal Article
joint
Eggshell Membrane (ESM)
low confidenceOverallB
omega
EPA
Also: Eicosapentaenoic acid
medium confidenceOverallB
Compare Claim Grade
Anti-inflammatory joint benefit in dogs
Active omega-3 responsible for most of the OA effect; dose reported per EPA content.
View studies & products →
ASave
Cited studies (4)
- Effect of an EPA-rich diet on ex-vivo cartilage metabolism Save — American Journal of Veterinary Research (2003) · in vitro
- Cyphenothrin (Veterinary Medicinal Products).Save — Food safety (Tokyo, Japan) (2023) · Journal Article
- Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic.Save — Cell (2024) · Journal Article
- Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals.Save — Nutrition research reviews (2025) · Journal Article; Review
Ingredient
Exclzyme Pet™
Also: Exclzyme Pet™
low confidenceOverallB
Ingredient
Flaxseed
Also: Flaxseed
low confidenceOverallB
Canine feeding studies show absorption of flaxseed ALA and some conversion to EPA/DPA, but not reliable conversion to DHA or demonstrated joint-pain benefit.
Cited studies (2)
- The balance of n-6 and n-3 fatty acids in canine, feline, and equine nutrition: exploring sources and the significance of alpha-linolenic acid.Save — Journal of animal science (2024) · Journal Article; Review
- Effects of dietary camelina, flaxseed, and canola oil supplementation on inflammatory and oxidative markers, transepidermal water loss, and coat quality in healthy adult dogs.Save — Frontiers in veterinary science (2023) · Journal Article
Ingredient
Folic Acid
Also: Folic Acid
low confidenceOverallB
joint
Glucosamine (HCl)
Also: Glucosamine Hydrochloride
medium confidenceOverallB
Compare Claim Grade
Reduces mild-to-moderate OA signs in dogs
Meta-analyses show a small but real benefit; effect is smaller than NSAIDs and slower to onset.
View studies & products →
BSave
Cited studies (5)
- Randomized controlled trial evaluating glucosamine–chondroitin in canine OA Save — The Veterinary Journal (2007) · RCT
- Glucosamine and chondroitin use in canines for osteoarthritis: A reviewSave — Open Veterinary Journal (2017) · SYSTEMATIC_REVIEW
- Glucosamine and chondroitin use in canines for osteoarthritis: A review.Save — Open veterinary journal (2017) · Journal Article; Review
- The Fate of Oral Glucosamine Traced by (13)C Labeling in the Dog.Save — Cartilage (2011) · Journal Article
- Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination with Glucosamine and Chondroitin in Arthritic Dogs.Save — Toxicology mechanisms and methods (2007) · Journal Article
joint
Green-Lipped Mussel
Also: GLM, Perna canaliculus, Green Lipped Mussel
high confidenceOverallB
Compare Claim Grade
Reduces OA pain and joint swelling
Several canine trials support use at ~30 mg/kg/day of stabilised powder.
View studies & products →
BSave
Cited studies (5)
- Green-lipped mussel powder in dogs with osteoarthritis Save — Australian Veterinary Journal (2002) · RCT
- The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of dogs with osteoarthritisSave — BMC Veterinary Research (2019) · RCT
- Clinical Guide to Obesity and Nonherbal Nutraceuticals in Canine Orthopedic Conditions.Save — The Veterinary clinics of North America. Small animal practice (2022) · Journal Article; Review
- Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus).Save — The Journal of nutrition (2002) · Journal Article; Research Support, Non-U.S. Gov't
- Comment on "Effects of different omega-3 sources, fish oil, krill oil, and green-lipped mussel against cytokine-mediated canine cartilage degradation" In Vitro Cell Dev Biol Anim. 2017 doi: 10.1007/s11626-016-0125-y.Save — In vitro cellular & developmental biology. Animal (2017) · Letter; Comment
omega-3
Green-Lipped Mussel Oil
low confidenceOverallB
mushroom
Maitake
low confidenceOverallB
Cited studies (1)
- Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer.Save — Nutrition and cancer (2017) · Journal Article
gut
Probiotic Blend
low confidenceOverallB
Compare Claim Grade
General gut and immune support
Effects depend on strain identity, CFU at expiry, and delivery survival.
View studies & products →
BSave
Cited studies (2)
- Label vs actual CFU in commercial pet probiotics Save — JAVMA (2011) · analytical
- Understanding the canine intestinal microbiota and its modification by pro-, pre- and synbiotics - what is the evidence?Save — Veterinary Medicine and Science (2016) · NARRATIVE_REVIEW
dental
ProDen Ascophyllum Nodosum
medium confidenceOverallB
Compare Claim Grade
Reduces dental plaque and calculus in dogs
Multiple RCTs on the ProDen PlaqueOff strain show plaque/tartar reduction.
View studies & products →
BSave
Cited studies (1)
- Effect of an Ascophyllum nodosum formulation on plaque and calculus in dogs Save — Journal of Veterinary Dentistry (2011) · RCT
botanical
Pumpkin
Also: Dehydrated Pumpkin, Dehydrated Pumpkin Powder, Pumpkin Powder, Cucurbita pepo
low confidenceOverallB
Canine research supports dietary fibre supplementation for gastrointestinal function, and pumpkin is a recognised mixed soluble/insoluble fibre source discussed in veterinary nutrition. There are no controlled clinical trials of this specific commercial dehydrated pumpkin product, so evidence is graded on the ingredient class and mechanism rather than product-level trials.
Cited studies (1)
- Identification of the PLATZ gene family in Cucurbita pepo and functional analysis of CpPLATZ4 in powdery mildew stress response.Save — Functional & integrative genomics (2025) · Journal Article
probiotic
Saccharomyces boulardii
Also: S. boulardii
medium confidenceOverallB
Compare Claim Grade
Reduces acute and antibiotic-associated diarrhoea in dogs
Randomised canine data support use for AAD and stress diarrhoea.
View studies & products →
BSave
Cited studies (1)
- S. boulardii for acute diarrhoea in dogs — RCT Save — Journal of Small Animal Practice (2020) · RCT
omega
Salmon Oil
medium confidenceOverallB
Compare Claim Grade
Same benefits as fish oil at label EPA/DHA dose
Bioequivalent when EPA+DHA dose is matched; sourcing and freshness matter more than species.
View studies & products →
ASave
Cited studies (4)
- Salmon oil supplementation and skin/coat quality in dogs Save — Veterinary Dermatology (1994) · RCT
- Protein hydrolysate and oil from fish waste reveal potential as dog food ingredients.Save — Frontiers in veterinary science (2024) · Journal Article
- Slipping on salmon oil: another cause of hypercalcaemia in dogs.Save — The Journal of small animal practice (2016) · Case Reports; Letter
- Salmon oil supplementation in dogs affects the blood flow of testicular arteries.Save — Reproduction in domestic animals = Zuchthygiene (2021) · Journal Article
liver
SAMe (S-Adenosylmethionine)
medium confidenceOverallB
Compare Claim Grade
Hepatoprotective; helps in copper and steroid hepatopathy
Multiple canine studies support use, often combined with silybin.
View studies & products →
BSave
Cited studies (4)
- SAMe in dogs with acetaminophen-induced hepatotoxicity Save — American Journal of Veterinary Research (2004) · RCT
- Nutritional Factors Related to Canine Gallbladder Diseases-A Scoping Review.Save — Veterinary sciences (2024) · Journal Article; Review
- Treatment and outcomes of dogs with hepatocutaneous syndrome or hepatocutaneous-associated hepatopathy.Save — Journal of veterinary internal medicine (2022) · Journal Article
- Hepatoprotective effects of S-adenosylmethionine and silybin on canine hepatocytes in vitro.Save — Journal of animal physiology and animal nutrition (2013) · Journal Article
joint
Undenatured Type II Collagen
Also: UC-II, Undenatured Collagen
medium confidenceOverallB
Compare Claim Grade
Improves lameness scores comparable to glucosamine+chondroitin
Small canine RCTs (40 mg/day) show improvement in force-plate and owner scores.
View studies & products →
BSave
Cited studies (1)
- Undenatured type II collagen for arthritic dogs Save — Journal of Veterinary Pharmacology and Therapeutics (2007) · RCT
vitamin
Vitamin E
Also: Tocopherol
medium confidenceOverallB
Compare Claim Grade
Antioxidant support especially with high PUFA diets
Requirement rises with fish/omega-3 intake.
View studies & products →
BSave
Cited studies (4)
- Vitamin E requirement in dogs consuming high-PUFA diets Save — Journal of Nutrition (1991) · controlled feeding
- Antioxidant function of coenzyme Q.Save — Journal of nutritional science and vitaminology (1992) · Journal Article; Review
- The immunomodulatory effects of vitamins in cancer.Save — Frontiers in immunology (2024) · Journal Article; Review
- The Role of Diet, Nutrition, and Supplements in Canine Atopic Dermatitis.Save — The Veterinary clinics of North America. Small animal practice (2025) · Journal Article; Review
probiotic
Weissella cibaria (OraCMU)
low confidenceOverallB
Ingredient
Zeolites
Also: Zeolites
low confidenceOverallB
UNCLASSIFIED
14 Strain Probiotic Blend
low confidenceOverallC
Cited studies (2)
- Effects of a polyphenol-rich extract blend, probiotics, and hydrolyzed fiber on quality of life and gut health markers in patients with irritable bowel syndrome-A randomized, double-blind, placebo-controlled trial.Save — Frontiers in nutrition (2025) · Journal Article
- An insight into the functional alterations in the gut microbiome of healthy adults in response to a multi-strain probiotic intake: a single arm open label trial.Save — Frontiers in cellular and infection microbiology (2023) · Clinical Trial; Journal Article
botanical
Ahiflower Oil (SDA Omega-3)
low confidenceOverallC
Cited studies (2)
- Can Ahiflower® (Buglossoides arvensis) seed-oil supplementation help overcome the adverse effects of imidacloprid in honey bees?Save — Comparative biochemistry and physiology. Toxicology & pharmacology : CBP (2025) · Journal Article
- Dietary Buglossoides Arvensis Oil Increases Circulating n-3 Polyunsaturated Fatty Acids in a Dose-Dependent Manner and Enhances Lipopolysaccharide-Stimulated Whole Blood Interleukin-10-A Randomized Placebo-Controlled Trial.Save — Nutrients (2017) · Journal Article; Randomized Controlled Trial
botanical
Alfalfa
low confidenceOverallC
Cited studies (3)
- Experimental models of atherosclerosis regression.Save — Atherosclerosis (1983) · Journal Article; Research Support, U.S. Gov't, P.H.S.; Review
- Effects of Dietary Alfalfa Meal Supplementation on the Growth Performance, Nutrient Apparent Digestibility, Serum Parameters, and Intestinal Microbiota of Raccoon Dogs (Nyctereutes procyonoides).Save — Animals : an open access journal from MDPI (2024) · Journal Article
- Insight into enhancing effect and mechanism of three Chinese herbal extracts on proliferation and lactation performance of canine and feline mammary epithelial cells.Save — Fitoterapia (2025) · Journal Article
Ingredient
amylase
Also: amylase
low confidenceOverallC
Cited studies (3)
- Diagnosis of pancreatitis in dogs and cats.Save — The Journal of small animal practice (2015) · Journal Article; Review
- Renal disposition of amylase, lipase, and lysozyme in the dog.Save — Veterinary pathology (1988) · Journal Article; Research Support, Non-U.S. Gov't
- Pancreatitis in dogs.Save — The Veterinary clinics of North America (1973) · Journal Article; Review
UNCLASSIFIED
Apple Cider Vinegar
low confidenceOverallC
whole food
Apple Skins (Polyphenols)
low confidenceOverallC
Ingredient
Arnica Montana
Also: Arnica Montana
low confidenceOverallC
Cited studies (3)
- Epidemiology and clinical management of Leishmania infantum, Dirofilaria immitis, and Dirofilaria repens infections in dogs in Ticino, Switzerland: A combined questionnaire-based and multicentric retrospective study.Save — Veterinary parasitology (2026) · Journal Article
- Sensitization and cross-reaction patterns in Danish Compositae-allergic patients.Save — Contact dermatitis (2001) · Journal Article
- Use of Homeopathic Arnica montana 30cH for Postoperative Analgesia in Female Dogs Undergoing Elective Ovariohysterectomy.Save — Homeopathy : the journal of the Faculty of Homeopathy (2022) · Journal Article
Ingredient
Ascorbic Acid
Also: Ascorbic Acid
low confidenceOverallC
Cited studies (3)
- Nutrition and bone disease in the dog and cat.Save — The Veterinary record (1976) · Journal Article; Review
- Influence of ascorbic acid and glutathione antioxidants on frozen-thawed canine semen.Save — Reproduction in domestic animals = Zuchthygiene (2009) · Journal Article; Research Support, Non-U.S. Gov't
- Ascorbic acid deficiency and hypertrophic osteodystrophy in the dog: a rebuttal.Save — The Cornell veterinarian (1979) · Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
vitamin
Ascorbyl Palmitate
low confidenceOverallC
Cited studies (2)
- Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics.Save — International journal of toxicology (2005) · Journal Article; Review
- Effect of three different preservative systems on the stability of extruded dog food subjected to ambient and high temperature storage.Save — The Journal of nutrition (1994) · Journal Article
Ingredient
Ashwagandha
Also: Ashwagandha
low confidenceOverallC
Cited studies (3)
- Efficacy of nutraceutical supplements containing Passiflora incarnata L., Withania somnifera (L.) Dunal and Taraxacum officinale (L.) weber ex F.H.Wigg. on markers of inflammation, oxidative stress and gut microbiota in senior dogs.Save — Frontiers in veterinary science (2025) · Journal Article
- In vitro screening of neuroprotective activity of Indian medicinal plant Withania somnifera.Save — Journal of nutritional science (2017) · Journal Article
- Ashwagandha (Withania somnifera) in insulin resistance and metabolic syndrome: A literature review on mechanisms.Save — Iranian journal of basic medical sciences (2026) · Journal Article; Review
botanical
Astragalus Root
low confidenceOverallC
Ingredient
B. clausii
Also: B. clausii
low confidenceOverallC
Ingredient
B. subtilis
Also: B. subtilis
low confidenceOverallC
UNCLASSIFIED
Bacillus lichenformis
low confidenceOverallC
Cited studies (3)
- Is this the historical 'cancer germ'?Save — Medical hypotheses (2003) · Journal Article
- Bacillus subtilis and Bacillus licheniformis reduce faecal protein catabolites concentration and odour in dogs.Save — BMC veterinary research (2020) · Journal Article
- Inhibitory Effect of Bacillus licheniformis Strains Isolated from Canine Oral Cavity.Save — Life (Basel, Switzerland) (2022) · Journal Article
UNCLASSIFIED
Bacillus pumilus
low confidenceOverallC
Cited studies (3)
- Effects of live Bacillus pumilus SG154 or a Lacticaseibacillus paracasei 327 postbiotic on apparent total tract nutrient digestibility and the immune function and fecal characteristics, metabolites, and microbiota of healthy adult dogs.Save — Journal of animal science (2025) · Journal Article
- Analysis of the Culturable Skin Microbiome of Horses from Southern Germany.Save — Microorganisms (2025) · Journal Article
- Deep Functional Profiling of Wild Animal Microbiomes Reveals Probiotic Bacillus pumilus Strains with a Common Biosynthetic Fingerprint.Save — International journal of molecular sciences (2022) · Journal Article
probiotic
Bacillus subtilis
low confidenceOverallC
Cited studies (3)
- Effect of Bacillus subtilis and Bacillus coagulans spores on induced allergic contact dermatitis in dogs.Save — Veterinary medicine and science (2024) · Journal Article
- Safety and efficacy of Calsporin(®) (Bacillus subtilis DSM 15544) as a feed additive for dogs.Save — EFSA journal. European Food Safety Authority (2017) · Journal Article
- Bacillus subtilis and Bacillus licheniformis reduce faecal protein catabolites concentration and odour in dogs.Save — BMC veterinary research (2020) · Journal Article
Ingredient
bacterial cultures
Also: bacterial cultures
low confidenceOverallC
Ingredient
Barley Grass
Also: Barley Grass
low confidenceOverallC
Cited studies (3)
- [Pharmacological effects of hordenine].Save — DTW. Deutsche tierarztliche Wochenschrift (1995) · English Abstract; Journal Article
- Hordeum pusillum heads injure dog.Save — Veterinary medicine (1946) · Journal Article
- Starch sources influence lipidaemia of diabetic dogs.Save — BMC veterinary research (2020) · Journal Article
organ
Beef Heart
low confidenceOverallC
organ
Beef Kidney
low confidenceOverallC
organ
Beef Liver
low confidenceOverallC
organ
Beef Spleen
low confidenceOverallC
Ingredient
Beet Pulp
Also: Beet Pulp
low confidenceOverallC
homeopathic
Berberis vulgaris
low confidenceOverallC
Cited studies (3)
- Gastrointestinal disorders of the cat.Save — The Veterinary clinics of North America. Small animal practice (1983) · Journal Article; Review
- Medicinal plant treatments for fleas and ear problems of cats and dogs in British Columbia, Canada.Save — Parasitology research (2008) · Journal Article; Research Support, Non-U.S. Gov't
- Protoscolecidal Effect of Berberis vulgaris Root Extract and Its Main Compound, Berberine in Cystic Echinococcosis.Save — Iranian journal of parasitology (2014) · Journal Article
Ingredient
Beta Carotene
Also: Beta Carotene
low confidenceOverallC
Cited studies (3)
- Pet Wellness and Vitamin A: A Narrative Overview.Save — Animals : an open access journal from MDPI (2024) · Journal Article; Review
- Recent Advances in the Nutrition and Metabolism of Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
other
Beta Glucan
low confidenceOverallC
Ingredient
Betaine HCL
Also: Betaine HCL
low confidenceOverallC
Cited studies (3)
- A bacterial TMAO transporter.Save — Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology (2002) · Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
- Methionine metabolism and liver disease.Save — Annual review of nutrition (2008) · Journal Article; Research Support, N.I.H., Extramural; Review
- Betaine and L-Carnitine Synergistically Influence the Metabolome and Immune Response in Dogs.Save — Animals : an open access journal from MDPI (2024) · Journal Article
digestive
Betaine Hydrochloride
low confidenceOverallC
probiotic
Bifidobacterium animalis
Also: B. animalis
medium confidenceOverallC
Compare Claim Grade
Reduces stress-associated diarrhoea (strain AHC7)
Strain-specific canine RCTs support this; not all Bifido products are equivalent.
View studies & products →
BSave
Cited studies (1)
- Bifidobacterium animalis AHC7 reduces acute idiopathic diarrhoea in dogs Save — British Journal of Nutrition (2009) · RCT
probiotic
Bifidobacterium bifidum
low confidenceOverallC
probiotic
Bifidobacterium breve
low confidenceOverallC
Cited studies (2)
- Effects of Lactiplantibacillus plantarum CBT LP3 and Bifidobacterium breve CBT BR3 supplementation on weight loss and gut microbiota of overweight dogs.Save — Scientific reports (2024) · Journal Article
- Metabolic and endocrine modulation of the gut-adipose tissue axis via pro-, pre-, and postbiotics in overweight dogs: A systematic review.Save — Domestic animal endocrinology (2026) · Journal Article; Review
probiotic
Bifidobacterium longum
low confidenceOverallC
Cited studies (3)
- Glucose-Lowering Effects and Safety of Bifidobacterium longum CKD1 in Diabetic Dogs and Cats.Save — Microorganisms (2025) · Journal Article
- Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis.Save — Nature nanotechnology (2023) · Journal Article; Research Support, Non-U.S. Gov't
- Safety and efficacy of a feed additive consisting of Bifidobacterium longum CNCM I-5642 (PP102I) for cats and dogs (Nestlé Enterprises S.A.).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
Ingredient
Biotin
Also: Biotin
low confidenceOverallC
Cited studies (1)
- A novel pseudotype derived of the canine distemper virus for adapter-mediated lentiviral transduction in vivo.Save — Molecular therapy. Methods & clinical development (2025) · Journal Article
Ingredient
BIOVAFLEX Egg Shell Membrane
Also: BIOVAFLEX Egg Shell Membrane
low confidenceOverallC
Cited studies (1)
- A Randomized, Double-Blind, Placebo-Controlled, Prospective Clinical Trial Evaluating Water-Soluble Chicken Eggshell Membrane for Improvement in Joint Health in Adults with Knee Osteoarthritis.Save — Journal of medicinal food (2019) · Journal Article; Randomized Controlled Trial
Ingredient
Black Cohosh Root
Also: Black Cohosh Root
low confidenceOverallC
Cited studies (2)
- Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms.Save — Obstetrics and gynecology (2005) · Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial
- Herbs of special interest to women.Save — Journal of the American Pharmaceutical Association (Washington, D.C. : 1996) (2000) · Journal Article; Review
whole food
Blueberry
low confidenceOverallC
topper
Bone Broth
low confidenceOverallC
Compare Claim Grade
Palatability, hydration and modest gelatin/amino acid content
No strong disease-modifying evidence; safe when made without onion/garlic/excess salt.
View studies & products →
CSave
Cited studies (3)
- Toxicological Safety Evaluation of a Bacillus acidopullulyticus Pullulanase.Save — Journal of food protection (1986) · Journal Article
- Implanted right atrial catheters for continuous infusion of solutions into dogs.Save — Journal of investigative surgery : the official journal of the Academy of Surgical Research (1993) · Journal Article; Research Support, U.S. Gov't, P.H.S.
- Infections caused by Moraxella, Moraxella urethralis, Moraxella-like groups M-5 and M-6, and Kingella kingae in the United States, 1953-1980.Save — Reviews of infectious diseases (1990) · Journal Article
Ingredient
brewer yeast
Also: brewer yeast
low confidenceOverallC
other
Brewer’s Yeast
low confidenceOverallC
whole food
Broccoli
low confidenceOverallC
enzyme
Bromelain
low confidenceOverallC
Cited studies (3)
- Detection and Inhibition of IgE for cross-reactive carbohydrate determinants evident in an enzyme-linked immunosorbent assay for detection of allergen-specific IgE in the sera of dogs and cats.Save — Veterinary dermatology (2020) · Journal Article
- The Canine Gut Health: The Impact of a New Feed Supplement on Microbiota Composition.Save — Animals : an open access journal from MDPI (2024) · Journal Article
- A Supplement with Bromelain, Lentinula edodes, and Quercetin: Antioxidant Capacity and Effects on Morphofunctional and Fecal Parameters (Calprotectin, Cortisol, and Intestinal Fermentation Products) in Kennel Dogs.Save — Veterinary sciences (2023) · Journal Article
UNCLASSIFIED
C8/C10 MCT powder
low confidenceOverallC
Ingredient
Calcium Carbonate
Also: Calcium Carbonate
low confidenceOverallC
Cited studies (3)
- The human pancreatic stone protein.Save — Biochimie (1988) · Journal Article; Review
- An exceptionally stable and widespread hydrated amorphous calcium carbonate precipitated by the dog vomit slime mold Fuligo septica (Myxogastria).Save — Scientific reports (2022) · Journal Article; Research Support, Non-U.S. Gov't
- Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide.Save — Current drug metabolism (2014) · Journal Article; Research Support, Non-U.S. Gov't; Review
Ingredient
Calcium Citrate
Also: Calcium Citrate
low confidenceOverallC
Cited studies (3)
- Response of canine plasma-ionized calcium and magnesium to the rapid infusion of acid-citrate-dextrose (ACD) solution.Save — Surgery (1971) · Journal Article
- Effect of acidification and alkalinisation on calcium and citrate metabolism in normal and parathyroidectomized dogs.Save — Acta physiologica Academiae Scientiarum Hungaricae (1970) · Journal Article
- SITE OF REABSORPTION OF CITRATE AND CALCIUM IN THE RENAL TUBULE OF THE DOG.Save — The American journal of physiology (1963) · Journal Article
Ingredient
Calcium Sulfate
Also: Calcium Sulfate
low confidenceOverallC
Ingredient
Canola Oil
Also: Canola Oil
low confidenceOverallC
Cited studies (2)
- Effects of dietary camelina, flaxseed, and canola oil supplementation on inflammatory and oxidative markers, transepidermal water loss, and coat quality in healthy adult dogs.Save — Frontiers in veterinary science (2023) · Journal Article
- Safety of Dietary Camelina Oil Supplementation in Healthy, Adult Dogs.Save — Animals : an open access journal from MDPI (2021) · Journal Article
Ingredient
Capric Acid
Also: Capric Acid
low confidenceOverallC
fatty acid
Caprylic Acid
low confidenceOverallC
Cited studies (3)
- Eastern brown snake (Pseudonaja textilis) envenomation in dogs and cats: Clinical signs, coagulation changes, brown snake venom antigen levels and treatment with a novel caprylic acid fractionated bivalent whole IgG equine antivenom.Save — Toxicon : official journal of the International Society on Toxinology (2017) · Case Reports; Journal Article
- Sensory Perception of Non-Deuterated and Deuterated Organic Compounds.Save — Chemistry (Weinheim an der Bergstrasse, Germany) (2021) · Journal Article
- Medium-chain fatty acid esters are effective even in azole-resistant Malassezia pachydermatis.Save — Mycoses (2022) · Journal Article
Ingredient
Carrots
Also: Carrots
low confidenceOverallC
Cited studies (3)
- Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality.Save — Current topics in microbiology and immunology (2009) · Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review
- Production of biopharmaceuticals and vaccines in plants via the chloroplast genome.Save — Biotechnology journal (2006) · Journal Article; Review
- Aqueous Ozone Efficacy for Inactivation of Foodborne Pathogens on Vegetables Used in Raw Meat-Based Diets for Companion Animals.Save — Journal of food protection (2023) · Journal Article; Research Support, U.S. Gov't, P.H.S.
botanical
Cat's Claw
low confidenceOverallC
Ingredient
Cayenne Pepper
Also: Cayenne Pepper
low confidenceOverallC
Cited studies (3)
- Occupational asthma due to different spices.Save — Allergy (1996) · Case Reports; Journal Article
- Medicinal and ethnoveterinary remedies of hunters in Trinidad.Save — BMC complementary and alternative medicine (2001) · Journal Article; Research Support, Non-U.S. Gov't
- Injury rates following conducted electrical weapons and other less-lethal force modalities in real-life police settings: a comparative literature review.Save — Forensic science, medicine, and pathology (2025) · Journal Article; Review; Comparative Study
Ingredient
Celery Seed
Also: Celery Seed
low confidenceOverallC
Cited studies (1)
- Safety and efficacy of a feed additive consisting of an essential oil obtained from the fruit of Apium graveolens L. (celery seed oil) for all animal species (FEFANA asbl).Save — EFSA journal. European Food Safety Authority (2024) · Journal Article
mushroom
Chaga
low confidenceOverallC
UNCLASSIFIED
Chaga extract
low confidenceOverallC
Cited studies (3)
- Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.Save — The Journal of veterinary medical science (2025) · Journal Article
- In vitro activity of Schinus terebinthifolius extract and fractions against Sporothrix brasiliensis.Save — Memorias do Instituto Oswaldo Cruz (2022) · Journal Article
- Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids.Save — Frontiers in pharmacology (2023) · Journal Article
botanical
Chamomile
low confidenceOverallC
Ingredient
Chicken cartilage (UC-II)
Also: Chicken cartilage (UC-II)
low confidenceOverallC
Ingredient
Chicken Gizzard
Also: Chicken Gizzard
low confidenceOverallC
Cited studies (3)
- Reduced expression of calponin in canine basilar artery after subarachnoid haemorrhage.Save — Acta neurochirurgica (1997) · Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- Detection of Toxocara species larvae in four Iranian free-range broiler farms.Save — BMC veterinary research (2022) · Journal Article
- Isolation and partial characterization of human platelet vinculin.Save — The Journal of cell biology (1985) · Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
Ingredient
Chicken Liver
Also: Chicken Liver
low confidenceOverallC
Cited studies (3)
- Polychlorinated Biphenyls in Food.Save — Environmental science & technology (2020) · Journal Article; Research Support, N.I.H., Extramural
- Ferimzone (Third Edition) (Pesticides).Save — Food safety (Tokyo, Japan) (2025) · Journal Article
- Pyridachlometyl (Pesticides).Save — Food safety (Tokyo, Japan) (2023) · Journal Article
Ingredient
Chicken with Ground Bone
Also: Chicken with Ground Bone
low confidenceOverallC
Cited studies (2)
- Bioavailability of zinc in ground beef.Save — Journal of animal science (1993) · Journal Article
- Effects of humic acid on broiler chickens.Save — Poultry science (2006) · Controlled Clinical Trial; Journal Article
Ingredient
chickpeas
Also: chickpeas
low confidenceOverallC
Ingredient
Chicory root extract (inulin, prebiotic fibre)
Also: Chicory root extract (inulin, prebiotic fibre)
low confidenceOverallC
Cited studies (1)
- Effect of chicory inulin-type fructan-containing snack bars on the human gut microbiota in low dietary fiber consumers in a randomized crossover trial.Save — The American journal of clinical nutrition (2020) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
botanical
Chinese Skullcap
low confidenceOverallC
algae
Chlorella
low confidenceOverallC
UNCLASSIFIED
Chlorella vulgaris
low confidenceOverallC
Ingredient
Choline Bitartrate
Also: Choline Bitartrate
low confidenceOverallC
Cited studies (3)
- Effective immuno-therapeutic treatment of Canine Leishmaniasis.Save — PLoS neglected tropical diseases (2023) · Journal Article; Research Support, Non-U.S. Gov't
- Methionine metabolism and liver disease.Save — Annual review of nutrition (2008) · Journal Article; Research Support, N.I.H., Extramural; Review
- Oleylphosphocholine versus Miltefosine for Canine Leishmaniasis.Save — The American journal of tropical medicine and hygiene (2025) · Journal Article; Comparative Study
Ingredient
Choline Chloride
Also: Choline Chloride
low confidenceOverallC
Cited studies (3)
- Effective immuno-therapeutic treatment of Canine Leishmaniasis.Save — PLoS neglected tropical diseases (2023) · Journal Article; Research Support, Non-U.S. Gov't
- Methionine metabolism and liver disease.Save — Annual review of nutrition (2008) · Journal Article; Research Support, N.I.H., Extramural; Review
- Choline chloride activates time-dependent and time-independent K+ currents in dog atrial myocytes.Save — The American journal of physiology (1994) · Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Chromium Polynicotinate
Also: Chromium Polynicotinate
low confidenceOverallC
Cited studies (2)
- Long-term effects of chromium, grape seed extract, and zinc on various metabolic parameters of rats.Save — Molecular and cellular biochemistry (2001) · Journal Article; Research Support, Non-U.S. Gov't
- Low dose chromium-polynicotinate or policosanol is effective in hypercholesterolemic children only in combination with glucomannan.Save — Atherosclerosis (2013) · Journal Article; Randomized Controlled Trial
Ingredient
cinnamon
Also: cinnamon
low confidenceOverallC
Ingredient
Citric Acid
Also: Citric Acid
low confidenceOverallC
Cited studies (3)
- Quantitative aspects of L(+)-lactate metabolism in human beings.Save — Ciba Foundation symposium (1982) · Journal Article; Review
- [Cobalamin deficiency in dogs and cats].Save — Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere (2018) · Journal Article; Review
- Association of plasma metabolites and cardiac mitochondrial function with heart failure progression.Save — ESC heart failure (2025) · Journal Article
botanical
Citrus Bioflavonoids
low confidenceOverallC
Cited studies (3)
- [Diet and migraine].Save — Revista de neurologia (1996) · English Abstract; Journal Article; Review
- Cellular electrophysiological effects of the citrus flavonoid hesperetin in dog and rabbit cardiac ventricular preparations.Save — Scientific reports (2024) · Journal Article
- PRELIMINARY STUDIES ON CITRUS MEDICA.Save — Journal of experimental medical sciences (1964) · Journal Article
Ingredient
Cobalt Carbonate
Also: Cobalt Carbonate
low confidenceOverallC
Ingredient
Cod Liver Oil
Also: Cod Liver Oil
low confidenceOverallC
heart
Coenzyme Q10
low confidenceOverallC
Compare Claim Grade
Adjunct in canine cardiomyopathy
Small canine data; often used empirically alongside standard cardiology treatment.
View studies & products →
CSave
Cited studies (3)
- Antioxidant function of coenzyme Q.Save — Journal of nutritional science and vitaminology (1992) · Journal Article; Review
- Coenzyme Q10 and cognition in atorvastatin treated dogs.Save — Neuroscience letters (2011) · Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
- Coenzyme Q10 and statins in heart failure: the dog that didn't bark.Save — Journal of the American College of Cardiology (2010) · Comment; Editorial
mineral
Colloidal Silver
low confidenceOverallC
immune
Colostrum
low confidenceOverallC
Compare Claim Grade
Modulates immune and gut markers
Small studies; effect sizes modest and variable by source.
View studies & products →
CSave
Cited studies (3)
- Canine and feline colostrum.Save — Reproduction in domestic animals = Zuchthygiene (2017) · Journal Article
- Passive immune transfer in puppies.Save — Animal reproduction science (2019) · Journal Article; Review
- Comparison of canine colostrum and milk using a multi-omics approach.Save — Animal microbiome (2024) · Journal Article
Ingredient
Copper Carbonate
Also: Copper Carbonate
low confidenceOverallC
Ingredient
Copper Gluconate
Also: Copper Gluconate
low confidenceOverallC
Cited studies (2)
- Experimental induction and treatment of toad poisoning in the dog.Save — Journal of the American Veterinary Medical Association (1975) · Journal Article
- Minimum inhibitory and bactericidal/fungicidal concentration of commercially available products containing essential oils, zinc gluconate, or 4% chlorhexidine for Malassezia pachydermatis, Pseudomonas aeruginosa, and multi-drug resistant Staphylococcus pseudintermedius canine clinical isolates.Save — Veterinary research communications (2024) · Journal Article
mushroom
Cordyceps
low confidenceOverallC
Ingredient
Corydalis
Also: Corydalis
low confidenceOverallC
Ingredient
Couch grass
Also: Couch grass
low confidenceOverallC
Cited studies (1)
- Aero-allergens in canine atopic dermatitis in southeastern Australia based on 1000 intradermal skin tests.Save — Australian veterinary journal (2000) · Journal Article
Ingredient
Cyanocobalamin (B12)
Also: Cyanocobalamin (B12)
low confidenceOverallC
Ingredient
Cyberlindnera jadinii
Also: Cyberlindnera jadinii
low confidenceOverallC
Ingredient
D-calcium Pantothenate
Also: D-calcium Pantothenate
low confidenceOverallC
Cited studies (2)
- Dietary Supplementation in Children with Autism Spectrum Disorders: Common, Insufficient, and Excessive.Save — Journal of the Academy of Nutrition and Dietetics (2015) · Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- Effects of vitamin-B complex supplementation on periodontal wound healing.Save — Journal of periodontology (2005) · Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
other
D-Mannose
low confidenceOverallC
Cited studies (3)
- Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.Save — Diabetes, obesity & metabolism (2012) · Journal Article
- Glycosylation in Canine Placentas.Save — Reproduction in domestic animals = Zuchthygiene (2024) · Journal Article
- Recent advances in antigen targeting to antigen-presenting cells in veterinary medicine.Save — Frontiers in immunology (2023) · Journal Article; Review; Research Support, Non-U.S. Gov't
botanical
Dandelion Root
low confidenceOverallC
UNCLASSIFIED
Deglycyrrhizinated Licorice
low confidenceOverallC
botanical
Deglycyrrhizinated Licorice (DGL)
low confidenceOverallC
Ingredient
Devil's Claw
Also: Devil's Claw
low confidenceOverallC
Cited studies (1)
- A randomized, double-blind, controlled study on the efficacy of an oral dietary supplement containing fish oil, ASU and phytotherapeutic extracts in canine osteoarthritis.Save — Frontiers in veterinary science (2025) · Journal Article
Ingredient
Dicalcium Phosphate
Also: Dicalcium Phosphate
low confidenceOverallC
Cited studies (1)
- Canine calcium phosphate uroliths. Etiopathogenesis, diagnosis, and management.Save — The Veterinary clinics of North America. Small animal practice (1999) · Case Reports; Journal Article; Review
gut
Digestive Enzymes
low confidenceOverallC
Compare Claim Grade
Meaningful benefit only in EPI-diagnosed dogs
Otherwise limited benefit in normal dogs on complete diets.
View studies & products →
CSave
Cited studies (3)
- Sulfation in dog.Save — Current drug metabolism (2005) · Journal Article; Review
- A review: Pancreatic enzymes in the treatment of chronic pancreatic insufficiency in companion animals.Save — Journal of veterinary internal medicine (2024) · Journal Article; Review
- Canine Gaucher disease--the enzymic defect.Save — The Australian journal of experimental biology and medical science (1979) · Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.
UNCLASSIFIED
Distilled Water
low confidenceOverallC
Cited studies (3)
- Canine sperm vitrification with nonpermeable cryoprotectants and coconut water extender.Save — Animal reproduction (2023) · Journal Article
- Nociception after extradural injection of sterile distilled water in anaesthetized dogs and cats.Save — Veterinary anaesthesia and analgesia (2020) · Letter
- Pharmacological modulation of bronchial hyperreactivity.Save — European journal of respiratory diseases. Supplement (1983) · Journal Article; Review
Ingredient
DMG
Also: DMG
low confidenceOverallC
Cited studies (3)
- Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina.Save — Drug delivery (2025) · Journal Article
- Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation.Save — Stem cell research & therapy (2025) · Journal Article
- Long-term occlusal tooth wear at the onset of permanent dentition.Save — Clinical oral investigations (2024) · Journal Article
Ingredient
Dried Aspergillus oryzae Fermentation Product
Also: Dried Aspergillus oryzae Fermentation Product
low confidenceOverallC
Ingredient
egg yolk
Also: egg yolk
low confidenceOverallC
UNCLASSIFIED
Enterococcus Faecium
low confidenceOverallC
Cited studies (3)
- Antimicrobial-Resistant Escherichia coli, Enterobacter cloacae, Enterococcus faecium, and Salmonella Kentucky Harboring Aminoglycoside and Beta-Lactam Resistance Genes in Raw Meat-Based Dog Diets, USA.Save — Foodborne pathogens and disease (2023) · Journal Article; Research Support, Non-U.S. Gov't
- The alleviating effects and mechanisms of Enterococcus faecium Kimate-X and Lactobacillus plantarum Kimate-F combination on canine inflammatory bowel disease.Save — Frontiers in veterinary science (2025) · Journal Article
- Vancomycin-resistant enterococci in cats and dogs.Save — Lancet (London, England) (1996) · Letter
Ingredient
Fenugreek Seed
Also: Fenugreek Seed
low confidenceOverallC
Cited studies (2)
- Hypocholesterolaemic effect of fenugreek seeds in dogs.Save — Atherosclerosis (1984) · Journal Article
- Implication of steroid saponins and sapogenins in the hypocholesterolemic effect of fenugreek.Save — Lipids (1991) · Journal Article
whole food
Fermented Cereal Grasses
low confidenceOverallC
Ingredient
Ferrous Sulfate
Also: Ferrous Sulfate
low confidenceOverallC
animal
Fish Collagen (Type II)
low confidenceOverallC
Canine evidence exists for undenatured type II collagen, but this fish collagen powder is not confirmed to match that studied form.
Ingredient
fos/fructo-oligosaccharides
Also: fos/fructo-oligosaccharides
low confidenceOverallC
mineral
Freeze-Dried Bone Powder
low confidenceOverallC
topper
Freeze-Dried Raw Meat
low confidenceOverallC
Compare Claim Grade
Palatability and moisture-free convenience
Nutritional benefit depends on the base diet; pathogen risk exists in raw formats.
View studies & products →
CSave
Cited studies (2)
- Rapid Screening for Salmonella in Raw Pet Food by Loop-Mediated Isothermal Amplification.Save — Journal of food protection (2021) · Journal Article
- Standardized amino acid digestibility and nitrogen-corrected true metabolizable energy of frozen and freeze-dried raw dog foods using precision-fed cecectomized and conventional rooster assays.Save — Journal of animal science (2023) · Journal Article
Ingredient
Galactooligosaccharides (GOS)
Also: Galactooligosaccharides (GOS)
low confidenceOverallC
botanical
Ginger Root
low confidenceOverallC
Ingredient
Glucose Oxidase (Aspergillus niger)
Also: Glucose Oxidase (Aspergillus niger)
low confidenceOverallC
Cited studies (2)
- Dietary supplementation of Aspergillus niger-expressed glucose oxidase ameliorates weaning stress and improves growth performance in weaning pigs.Save — Journal of animal physiology and animal nutrition (2022) · Journal Article; Randomized Controlled Trial, Veterinary
- Improvement Strategies, Cost Effective Production, and Potential Applications of Fungal Glucose Oxidase (GOD): Current Updates.Save — Frontiers in microbiology (2017) · Journal Article; Review
topper
Goat Milk
low confidenceOverallC
Compare Claim Grade
Palatability and probiotic delivery (if raw/fermented)
Modest evidence for tolerance vs cow milk; not a meaningful nutrient source.
View studies & products →
CSave
Ingredient
Grape Seed Extract
Also: Grape Seed Extract
low confidenceOverallC
Cited studies (3)
- Grape seed proanthocyanidin improves intestinal inflammation in canine through regulating gut microbiota and bile acid compositions.Save — FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2023) · Journal Article
- A mixed grape and blueberry extract is safe for dogs to consume.Save — BMC veterinary research (2016) · Journal Article
- Effects of grape seed extract, lutein, and fish oil on responses of canine lens epithelial cells in vitro.Save — American journal of veterinary research (2018) · Journal Article
homeopathic
Graphites
low confidenceOverallC
UNCLASSIFIED
Green Tea
low confidenceOverallC
Cited studies (3)
- Endothelium-derived hyperpolarizing factor.Save — Clinical and experimental pharmacology & physiology (1996) · Journal Article; Review
- Exposure and toxicity of green tea polyphenols in fasted and non-fasted dogs.Save — Toxicology (2009) · Journal Article; Multicenter Study; Research Support, N.I.H., Extramural
- [Diet and migraine].Save — Revista de neurologia (1996) · English Abstract; Journal Article; Review
Ingredient
Gut Seal
Also: Gut Seal
low confidenceOverallC
Cited studies (3)
- Histopathological findings in harbour seals (Phoca vitulina) found dead on the German North sea coast.Save — Journal of comparative pathology (1990) · Journal Article; Research Support, Non-U.S. Gov't
- Experimental comparison of endoscopic yttrium-aluminum-garnet laser, electrosurgery, and heater probe for canine gut arterial coagulation. Importance of compression and avoidance of erosion.Save — Gastroenterology (1987) · Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
- Colonic inhibition of gastric acid secretion in the dog.Save — Gastroenterology (1980) · Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Ingredient
Healthy Gut
Also: Healthy Gut
low confidenceOverallC
Cited studies (3)
- The Gut Microbiome of Dogs and Cats, and the Influence of Diet.Save — The Veterinary clinics of North America. Small animal practice (2021) · Journal Article; Review
- The Role of the Canine Gut Microbiome and Metabolome in Health and Gastrointestinal Disease.Save — Frontiers in veterinary science (2019) · Journal Article; Review
- Artificial-enzymes-armed Bifidobacterium longum probiotics for alleviating intestinal inflammation and microbiota dysbiosis.Save — Nature nanotechnology (2023) · Journal Article; Research Support, Non-U.S. Gov't
botanical
Hemp Seed Oil
low confidenceOverallC
Cited studies (3)
- Dietary supplementation of hemp oil in teddy dogs: Effect on apparent nutrient digestibility, blood biochemistry and metabolomics.Save — Bioengineered (2022) · Journal Article; Research Support, Non-U.S. Gov't
- Hemp Seed Cake as a Novel Ingredient for Dog's Diet.Save — Frontiers in veterinary science (2021) · Journal Article
- Oral Lipids/Fatty Acids Supplements and Eczema: What Is Known?Save — Dermatitis : contact, atopic, occupational, drug (2026) · Journal Article; Review
UNCLASSIFIED
Herbal Tinctures of
low confidenceOverallC
Cited studies (1)
- Evaluation of the Efficacy of Crataegus oxyacantha in Dogs with Early-Stage Heart Failure.Save — Homeopathy : the journal of the Faculty of Homeopathy (2020) · Journal Article
mineral
Himalayan Salt
low confidenceOverallC
Ingredient
honey
Also: honey
low confidenceOverallC
botanical
Horsetail
low confidenceOverallC
Cited studies (3)
- Plasma activation of plant-based biostimulants enhances growth and defense responses in soybean (Glycine max (L.)).Save — BMC plant biology (2026) · Journal Article
- Chemical, antioxidant and cytotoxic profile of hydroalcoholic extracts of plants from Southern Brazil and their activity against pathogenic fungi isolated from dogs and cats with sensitivity and resistance to conventional antifungals.Save — Natural product research (2022) · Journal Article
- Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?Save — Journal of ethnopharmacology (2019) · Journal Article; Review
Ingredient
Hyaluronic Acid (as Sodium Hyaluronate)
Also: Hyaluronic Acid (as Sodium Hyaluronate)
low confidenceOverallC
Cited studies (3)
- Slow-acting, disease-modifying osteoarthritis agents.Save — The Veterinary clinics of North America. Small animal practice (1997) · Journal Article; Research Support, Non-U.S. Gov't; Review
- Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory.Save — Frontiers in veterinary science (2019) · Journal Article; Review
- Pentoxifylline in Dogs With Osteoarthritis: Comparative Treatment and Efficacy Analysis With Meloxicam.Save — Veterinary medicine and science (2025) · Journal Article; Comparative Study; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Hydrastis
low confidenceOverallC
Cited studies (3)
- Medicinal plants used in British Columbia, Canada for reproductive health in pets.Save — Preventive veterinary medicine (2009) · Journal Article; Research Support, Non-U.S. Gov't
- Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada.Save — Veterinary parasitology (2007) · Journal Article; Research Support, Non-U.S. Gov't
- Inhibition of H1N1 influenza A virus growth and induction of inflammatory mediators by the isoquinoline alkaloid berberine and extracts of goldenseal (Hydrastis canadensis).Save — International immunopharmacology (2011) · Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Hypericum
low confidenceOverallC
Cited studies (3)
- Regulation of hepatic energy metabolism by the nuclear receptor PXR.Save — Biochimica et biophysica acta (2016) · Journal Article; Research Support, Non-U.S. Gov't; Review
- Antimicrobial and anti-biofilm activity of Hypericum brasiliense extract and its fractions on Staphylococcus of canine origin.Save — Scientific reports (2025) · Journal Article
- Serotonergic anti-depressants and ethanol withdrawal syndrome: a review.Save — Alcohol and alcoholism (Oxford, Oxfordshire) (2008) · Journal Article; Review
Ingredient
Iron Proteinate
Also: Iron Proteinate
low confidenceOverallC
Cited studies (1)
- Ultracytochemistry of glycosaminoglycans in the canine knee synovium.Save — Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft (2001) · Journal Article
amino acid
L-Glutamine
low confidenceOverallC
Cited studies (3)
- Hepatic encephalopathy in dogs and cats.Save — Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) (2016) · Journal Article; Review
- Characteristics of the Digestive Tract of Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
Ingredient
L-Glutathione
Also: L-Glutathione
low confidenceOverallC
Cited studies (3)
- Experimental onion-induced hemolytic anemia in dogs.Save — Veterinary pathology (1985) · Journal Article
- Gamma-Glutamyl Transferase (γ-GT) - an old dog with new tricks?Save — Liver international : official journal of the International Association for the Study of the Liver (2022) · Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
- Reactive oxygen species, glutathione, and vitamin E concentrations in dogs with hemolytic or nonhemolytic anemia.Save — Journal of veterinary internal medicine (2020) · Journal Article
Ingredient
L-lysine
Also: L-lysine
low confidenceOverallC
calming
L-Theanine
Also: Theanine
low confidenceOverallC
Compare Claim Grade
Reduces situational anxiety in dogs
Open-label and small blinded studies suggest benefit for storm/travel anxiety.
View studies & products →
CSave
Cited studies (5)
- L-theanine for canine anxiety Save — Veterinary Record (2010) · open-label
- Anxitane (L-theanine) tablets reduce fear of human beings in a laboratory model of anxiety-related behavior in dogsSave — Journal of Veterinary Behavior (2010) · RCT
- Inhibitory activity of a green tea extract and some of its constituents on multidrug resistance-associated protein 2 functionality.Save — Planta medica (2005) · Journal Article; Research Support, Non-U.S. Gov't
- l-theanine attenuates abstinence signs in morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in mice.Save — Pharmacology, biochemistry, and behavior (2012) · Journal Article; Research Support, N.I.H., Extramural
- Effect of l-theanine tablets in reducing stress-related emotional signs in cats: an open-label field study.Save — Irish veterinary journal (2018) · Journal Article
amino_acid
L-Tryptophan
low confidenceOverallC
Cited studies (3)
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
- The Role of the Canine Gut Microbiome and Metabolome in Health and Gastrointestinal Disease.Save — Frontiers in veterinary science (2019) · Journal Article; Review
- Recent Advances in the Nutrition and Metabolism of Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
Ingredient
lactase
Also: lactase
low confidenceOverallC
probiotic
Lactobacillus acidophilus
Also: L. acidophilus
low confidenceOverallC
Compare Claim Grade
Improves stool quality in healthy dogs
Strain-specific; general genus claims are weak.
View studies & products →
CSave
Cited studies (3)
- Developing Gut-Healthy Strains for Pets: Probiotic Potential and Genomic Insights of Canine-Derived Lactobacillus acidophilus GLA09.Save — Microorganisms (2025) · Journal Article
- Safety and efficacy of a feed additive consisting of Enterococcus faecium NBIMCC 8270, Lactobacillus acidophilus NBIMCC 8242, Lactobacillus helveticus NBIMCC 8269, Lactobacillus delbrueckii ssp. lactis NBIMCC 8250, L. delbrueckii ssp. bulgaricus NBIMCC 8244 and Streptococcus thermophilus NBIMCC 8253 (Probiotic Lactina®) for cats and dogs (Lactina Ltd.).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
- Preparation and application characteristics of microencapsulated Lactobacillus acidophilus as probiotics for dogs.Save — Pakistan journal of pharmaceutical sciences (2015) · Journal Article; Research Support, Non-U.S. Gov't
probiotic
Lactobacillus casei
low confidenceOverallC
Cited studies (3)
- Effect of recombinant lactobacillus expressing canine GM-CSF on immune function in dogs.Save — Journal of microbiology and biotechnology (2009) · Journal Article; Research Support, Non-U.S. Gov't
- Safety and efficacy of a feed additive consisting of Lacticaseibacillus caseiIDAC 210415-01, Limosilactobacillus fermentumIDAC 210415-02, Levilactobacillus brevisIDAC 051120-02 and Enterococcus faeciumIDAC 181218-03 (K-9 Heritage Probiotic Blend®) for dogs (CanBiocin Inc.).Save — EFSA journal. European Food Safety Authority (2023) · Journal Article
- Antimicrobial activity of Lactobacillus casei on Staphylococcus pseudintermedius isolates.Save — Veterinary dermatology (2025) · Journal Article
other
Lactobacillus Fermentation Postbiotic (Tynagen)
low confidenceOverallC
probiotic
Lactobacillus helveticus
low confidenceOverallC
Cited studies (3)
- Lactobacillus helveticus-derived postbiotic and live Saccharomyces boulardii restore gut microbiota after antibiotic disturbance in an in vitro canine gut model.Save — Beneficial microbes (2025) · Journal Article
- Safety and efficacy of a feed additive consisting of Enterococcus faecium NBIMCC 8270, Lactobacillus acidophilus NBIMCC 8242, Lactobacillus helveticus NBIMCC 8269, Lactobacillus delbrueckii ssp. lactis NBIMCC 8250, L. delbrueckii ssp. bulgaricus NBIMCC 8244 and Streptococcus thermophilus NBIMCC 8253 (Probiotic Lactina®) for cats and dogs (Lactina Ltd.).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
- A specific blend of prebiotics and postbiotics improved the gut microbiome of dogs with soft stools in the in vitro Simulator of the Canine Intestinal Microbial Ecosystem.Save — Journal of animal science (2025) · Journal Article
probiotic
Lactobacillus lactis
low confidenceOverallC
Cited studies (3)
- Safety and efficacy of a feed additive consisting of Enterococcus faecium NBIMCC 8270, Lactobacillus acidophilus NBIMCC 8242, Lactobacillus helveticus NBIMCC 8269, Lactobacillus delbrueckii ssp. lactis NBIMCC 8250, L. delbrueckii ssp. bulgaricus NBIMCC 8244 and Streptococcus thermophilus NBIMCC 8253 (Probiotic Lactina®) for cats and dogs (Lactina Ltd.).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
- Biological and genetic classification of canine intestinal lactic acid bacteria and bifidobacteria.Save — Microbiology and immunology (2007) · Journal Article; Research Support, Non-U.S. Gov't
- Safety and efficacy of a feed additive consisting of viable cells of Lactobacillus acidophilusCNCM I-3231, Ligilactobacillus salivariusCNCM I-3233, Lactiplantibacillus plantarumCNCM I-3232, Lacticaseibacillus rhamnosusCNCM I-4427, and Bifidobacterium animalis subsp. lactis CNCM I-3993 (FlorEquilibre® Chien) for dogs (Wamine SAS).Save — EFSA journal. European Food Safety Authority (2025) · Journal Article
probiotic
Lactobacillus plantarum
low confidenceOverallC
probiotic
Lactobacillus rhamnosus
low confidenceOverallC
Cited studies (3)
- Canine Microencapsulated Probiotic Formulations Modulate Immunity and Improve Acute Diarrhea in Dogs.Save — Probiotics and antimicrobial proteins (2026) · Journal Article
- Management of dog sperm parameters and gut microbiota composition with Lactobacillus rhamnosus supplementation.Save — Veterinary research communications (2023) · Journal Article
- Characterization of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02 and Assessment of Their Potential for the Prevention of Gastrointestinal Infections in an Experimental Canine Model.Save — Frontiers in microbiology (2019) · Journal Article
organ
Lamb Liver
low confidenceOverallC
UNCLASSIFIED
Larch Arabinogalactan
low confidenceOverallC
Cited studies (2)
- Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance.Save — Nutrients (2020) · Journal Article
- Immunological activity of larch arabinogalactan and Echinacea: a preliminary, randomized, double-blind, placebo-controlled trial.Save — Alternative medicine review : a journal of clinical therapeutic (2002) · Clinical Trial; Journal Article; Randomized Controlled Trial
botanical
Leafy Greens Blend (Spinach, Wheat & Barley Grass)
low confidenceOverallC
UNCLASSIFIED
Levilactobacillus Brevis
low confidenceOverallC
Cited studies (1)
- Safety and efficacy of a feed additive consisting of Lacticaseibacillus caseiIDAC 210415-01, Limosilactobacillus fermentumIDAC 210415-02, Levilactobacillus brevisIDAC 051120-02 and Enterococcus faeciumIDAC 181218-03 (K-9 Heritage Probiotic Blend®) for dogs (CanBiocin Inc.).Save — EFSA journal. European Food Safety Authority (2023) · Journal Article
Ingredient
Linseed meal
Also: Linseed meal
low confidenceOverallC
mushroom
Lion's Mane Mushroom
low confidenceOverallC
Compare Claim Grade
Cognitive and nerve-growth-factor support
Rodent and human pilot data; no controlled canine trials yet.
View studies & products →
CSave
Ingredient
Liver Tonic
Also: Liver Tonic
low confidenceOverallC
Cited studies (3)
- Chronic methylmercurialism in the cat.Save — Australian veterinary journal (1978) · Journal Article
- [Lafora disease in a Beagle - diagnosis and therapy].Save — Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere (2020) · Case Reports; Journal Article
- Fatal metaldehyde poisoning in a dog confirmed by gas chromatography.Save — BMC veterinary research (2020) · Case Reports; Journal Article
Ingredient
Magnesium Citrate
Also: Magnesium Citrate
low confidenceOverallC
Cited studies (2)
- Preliminary non-comparative evaluation of an adapted colonoscopy preparation protocol for dogs using sodium picosulphate and magnesium citrate.Save — The Veterinary record (2026) · Journal Article
- Effect of Supplementation With Omega-3 Fatty Acids, Magnesium, and Zinc on Canine Behavioral Disorders: Results of a Pilot Study.Save — Topics in companion animal medicine (2018) · Journal Article
Ingredient
Magnesium Stearate
Also: Magnesium Stearate
low confidenceOverallC
Ingredient
Maltodextrin
Also: Maltodextrin
low confidenceOverallC
Ingredient
Manganese Sulfate
Also: Manganese Sulfate
low confidenceOverallC
Ingredient
Manganese Sulphate
Also: Manganese Sulphate
low confidenceOverallC
Cited studies (1)
- Effects of brief and intermediate exposures to sulfate submicron aerosols and sulfate injections and cardiopulmonary function of dogs and tracheal mucous velocity of sheep.Save — Journal of toxicology and environmental health (1981) · Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
fat
MCT Powder (C8/C10)
low confidenceOverallC
calming
Melatonin
Also: Melatonin
low confidenceOverallC
Compare Claim Grade
Aids sleep and reduces noise-phobia signs
Mostly clinical experience and small case series; behavioural plan should be first-line.
View studies & products →
CSave
Cited studies (4)
- Melatonin for canine noise phobia — case series Save — JAAHA (1999) · case series
- Essential Oils and Melatonin as Functional Ingredients in Dogs.Save — Animals : an open access journal from MDPI (2022) · Journal Article; Review
- Melatonin Supplementation for the Cryopreservation of Canine Sperm.Save — Biopreservation and biobanking (2023) · Journal Article
- Serum Melatonin Values in Normal Dogs and Dogs with Seizures.Save — Journal of the American Animal Hospital Association (2019) · Journal Article
botanical
Milk Thistle
Also: Silybum marianum, Silymarin
medium confidenceOverallC
Compare Claim Grade
Hepatoprotective adjunct for liver disease
Silybin-phosphatidylcholine complexes have the best pharmacokinetic data in dogs.
View studies & products →
CSave
Cited studies (4)
- Silybin-phosphatidylcholine complex pharmacokinetics in dogs Save — American Journal of Veterinary Research (2005) · PK study
- Effects of Gingko biloba and Milk Thistle Extracts on Biomarkers of Antioxidants Status and Liver Function in Healthy Dogs.Save — Veterinary sciences (2025) · Journal Article
- Liver failure in a dog following suspected ingestion of blue-green algae (Microcystis spp.): a case report and review of the toxin.Save — Journal of the American Animal Hospital Association (2013) · Case Reports; Journal Article; Review
- Use of Milk Thistle in Farm and Companion Animals: A Review.Save — Planta medica (2023) · Review; Journal Article
botanical
Milk Thistle Seed
low confidenceOverallC
excipient
Mixed Tocopherols
low confidenceOverallC
Cited studies (3)
- A new injectable liquid crystal system for one month delivery of leuprolide.Save — Journal of controlled release : official journal of the Controlled Release Society (2014) · Journal Article
- Lipophilic constituents from aerial and root parts of Mercurialis perennis L.Save — Phytochemical analysis : PCA (2010) · Journal Article
- Effect of dietary antioxidants on free radical damage in dogs and cats.Save — Journal of animal science (2024) · Journal Article
Ingredient
Moisture
Also: Moisture
low confidenceOverallC
Cited studies (3)
- Management of anorexia in dogs and cats.Save — The Veterinary clinics of North America. Small animal practice (2006) · Journal Article; Review
- Emollients to Prevent Pediatric Eczema: A Randomized Clinical Trial.Save — JAMA dermatology (2025) · Journal Article
- [Larva migrans].Save — Sante (Montrouge, France) (1995) · English Abstract; Journal Article; Review
Ingredient
Molasses
Also: Molasses
low confidenceOverallC
Cited studies (2)
- Sulfadiazines reduce gingivitis and plaque formation in beagle dogs.Save — Journal of clinical periodontology (1990) · Journal Article
- In vitro digestion and fermentation characteristics of temulose molasses, a coproduct of fiberboard production, and select temulose fractions using canine fecal inoculum.Save — Journal of agricultural and food chemistry (2011) · Journal Article
Ingredient
Montmorillonite Clay
Also: Montmorillonite Clay
low confidenceOverallC
joint
MSM
Also: Methylsulfonylmethane
low confidenceOverallC
Compare Claim Grade
Adjunctive OA pain relief
Mostly extrapolated from human OA trials; limited dog-specific RCTs.
View studies & products →
CSave
Cited studies (3)
- A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.Save — British journal of pharmacology (2021) · Journal Article; Research Support, Non-U.S. Gov't
- Digestiblity and metabolisable energy in high-ash poultry meal and plant protein ingredients for dogs.Save — Archives of animal nutrition (2025) · Journal Article
- Severe acute respiratory syndrome.Save — Medical science monitor : international medical journal of experimental and clinical research (2003) · Editorial
Ingredient
Mucopolysaccharides (porcine source of chondroitin sulfate & hyaluronic acid)
Also: Mucopolysaccharides (porcine source of chondroitin sulfate & hyaluronic acid)
low confidenceOverallC
Cited studies (1)
- Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties.Save — The Journal of bone and joint surgery. American volume (2006) · Comparative Study; Journal Article
other
N-Acetyl-Glucosamine
low confidenceOverallC
UNCLASSIFIED
Natural curcumin
low confidenceOverallC
Cited studies (3)
- A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction.Save — Advanced materials (Deerfield Beach, Fla.) (2024) · Journal Article
- Does Chemically Modified Curcumin Control the Progression of Periodontitis? A Systematic Review.Save — Journal of experimental pharmacology (2021) · Journal Article; Review
- A Nutritional Supplement Containing Curcumin C3 Complex, Glucosamine, and Chondroitin Alleviates Osteoarthritis in Mice and Canines.Save — Veterinary sciences (2025) · Journal Article
Ingredient
Niacinamide (B3)
Also: Niacinamide (B3)
low confidenceOverallC
Cited studies (1)
- Niacin Deficiency.Save — (2026) · Study Guide
homeopathic
Nux Vomica
low confidenceOverallC
Ingredient
Oat Flour
Also: Oat Flour
low confidenceOverallC
Cited studies (3)
- Validation of the ANSR Salmonella method for detection of Salmonella spp. in a variety of foods. Performance Tested Method 061203.Save — Journal of AOAC International (2014) · Journal Article
- Metabolic and hormonal effects of whole grains of rye, oats and wheat in dog food.Save — Journal of animal science (2026) · Journal Article
- Development and Immature Mortality of the Sawtoothed Grain Beetle (Coleoptera: Silvanidae), on Different Sorghum Fractions and Different Temperatures.Save — Journal of economic entomology (2023) · Journal Article
botanical
Olive Leaf
low confidenceOverallC
UNCLASSIFIED
OraCMU® (Weissella cibaria CMU)
low confidenceOverallC
Cited studies (2)
- Effects of probiotic bacterium Weissella cibaria CMU on periodontal health and microbiota: a randomised, double-blind, placebo-controlled trial.Save — BMC oral health (2020) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
- Exploratory randomized trial of Weissella cibaria CMU and oral microbiome changes in peri implant mucositis.Save — Scientific reports (2026) · Journal Article; Randomized Controlled Trial
botanical
Oregano Leaf
low confidenceOverallC
UNCLASSIFIED
Organic aloe vera
low confidenceOverallC
Cited studies (3)
- Citric acid cross-linking of a hydrogel from Aloe vera (Aloe barbadensis M.) engenders a pH-responsive, superporous, and smart material for drug delivery.Save — RSC advances (2024) · Journal Article
- Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?Save — Journal of ethnopharmacology (2019) · Journal Article; Review
- Time-Dependent Inhibition of hOAT1 and hOAT3 by Anthraquinones.Save — Biological & pharmaceutical bulletin (2015) · Journal Article; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic apple skins
low confidenceOverallC
Cited studies (2)
- Oral birch pollen immunotherapy with apples: Results of a phase II clinical pilot study.Save — Immunity, inflammation and disease (2021) · Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't
- Structured Fresh Apple Consumption for Birch Pollen Food Allergy Syndrome in an Uncontrolled Phase II/III Trial.Save — The journal of allergy and clinical immunology. In practice (2025) · Journal Article; Clinical Trial, Phase II; Clinical Trial, Phase III
Ingredient
Organic Apples
Also: Organic Apples
low confidenceOverallC
Ingredient
Organic Beets
Also: Organic Beets
low confidenceOverallC
Cited studies (2)
- Organic matter disappearance and production of short- and branched-chain fatty acids from selected fiber sources used in pet foods by a canine in vitro fermentation model1.Save — Journal of animal science (2019) · Journal Article
- Effects of high inclusion of soybean hulls on apparent total tract macronutrient digestibility, fecal quality, and fecal fermentative end-product concentrations in extruded diets of adult dogs.Save — Journal of animal science (2019) · Comparative Study; Journal Article
UNCLASSIFIED
Organic blueberries
low confidenceOverallC
Cited studies (1)
- Substrate degradation and postbiotic analysis of alternative fiber ingredients fermented using an in vitro canine fecal inoculum model.Save — Journal of animal science (2023) · Journal Article
UNCLASSIFIED
Organic broccoli
low confidenceOverallC
Cited studies (1)
- Microbial succession associated with organic matter decomposition during thermophilic composting of organic waste.Save — Waste management & research : the journal of the International Solid Wastes and Public Cleansing Association, ISWA (2005) · Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Organic cauliflower
Also: Organic cauliflower
low confidenceOverallC
UNCLASSIFIED
Organic Chaga Mushrooms
low confidenceOverallC
Ingredient
organic coconut oil
Also: organic coconut oil
low confidenceOverallC
UNCLASSIFIED
Organic cranberries
low confidenceOverallC
Cited studies (2)
- Substrate degradation and postbiotic analysis of alternative fiber ingredients fermented using an in vitro canine fecal inoculum model.Save — Journal of animal science (2023) · Journal Article
- Composition of sugars, organic acids, and total phenolics in 25 wild or cultivated berry species.Save — Journal of food science (2012) · Journal Article; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic fennel
low confidenceOverallC
UNCLASSIFIED
Organic Glycerin
low confidenceOverallC
Cited studies (3)
- Toxicological studies of deltamethrin.Save — International journal of tissue reactions (1984) · Journal Article; Research Support, Non-U.S. Gov't
- Regulation of organic cation transport in IHKE-1 and LLC-PK1 cells. Fluorometric studies with 4-(4-dimethylaminostyryl)-N-methylpyridinium.Save — The Journal of pharmacology and experimental therapeutics (1998) · Journal Article; Research Support, Non-U.S. Gov't
- Properties and regulation of organic cation transport in freshly isolated human proximal tubules.Save — The Journal of biological chemistry (2001) · Journal Article; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic goldenseal
low confidenceOverallC
UNCLASSIFIED
Organic kale
low confidenceOverallC
UNCLASSIFIED
Organic kelp
low confidenceOverallC
Cited studies (2)
- Supplementation of Ascophyllum nodosum meal and monensin: Effects on diversity and relative abundance of ruminal bacterial taxa and the metabolism of iodine and arsenic in lactating dairy cows.Save — Journal of dairy science (2022) · Journal Article; Randomized Controlled Trial, Veterinary
- Microwave-assisted micellar extraction of organic and inorganic iodines using zwitterionic surfactants.Save — Journal of chromatography. A (2017) · Evaluation Study; Journal Article
Ingredient
Organic Lions Mane (Hericium erinaceus)
Also: Organic Lions Mane (Hericium erinaceus)
low confidenceOverallC
botanical
Organic Mushroom Blend
low confidenceOverallC
UNCLASSIFIED
Organic parsley
low confidenceOverallC
Cited studies (1)
- Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada.Save — Veterinary parasitology (2007) · Journal Article; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic raspberries
low confidenceOverallC
Cited studies (1)
- Composition of sugars, organic acids, and total phenolics in 25 wild or cultivated berry species.Save — Journal of food science (2012) · Journal Article; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic shiitake mushroom extract
low confidenceOverallC
Cited studies (1)
- The anticaries effect of a food extract (shiitake) in a short-term clinical study.Save — Journal of biomedicine & biotechnology (2012) · Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic slippery elm
low confidenceOverallC
Ingredient
Organic Squash
Also: Organic Squash
low confidenceOverallC
Cited studies (3)
- Ethnoveterinary medicines used to treat endoparasites and stomach problems in pigs and pets in British Columbia, Canada.Save — Veterinary parasitology (2007) · Journal Article; Research Support, Non-U.S. Gov't
- True nutrient and amino acid digestibility of dog foods made with human-grade ingredients using the precision-fed cecectomized rooster assay.Save — Translational animal science (2020) · Journal Article
- Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?Save — Journal of ethnopharmacology (2019) · Journal Article; Review
digestive
Ox Bile
low confidenceOverallC
Ingredient
Palm Oil
Also: Palm Oil
low confidenceOverallC
Ingredient
Pantothenic Acid
Also: Pantothenic Acid
low confidenceOverallC
enzyme
Papain
low confidenceOverallC
Cited studies (3)
- Canine models of asthma and COPD.Save — Pulmonary pharmacology & therapeutics (2008) · Journal Article; Review
- Elastase and papain inhibition by serum of mammals.Save — Scandinavian journal of clinical and laboratory investigation (1989) · Comparative Study; Journal Article
- Experimental papain-induced emphysema in dogs.Save — The American review of respiratory disease (1970) · Journal Article
Ingredient
Papaya
Also: Papaya
low confidenceOverallC
Ingredient
Passion Flower
Also: Passion Flower
low confidenceOverallC
Cited studies (3)
- Efficacy of nutraceutical supplements containing Passiflora incarnata L., Withania somnifera (L.) Dunal and Taraxacum officinale (L.) weber ex F.H.Wigg. on markers of inflammation, oxidative stress and gut microbiota in senior dogs.Save — Frontiers in veterinary science (2025) · Journal Article
- Is It Possible to Mitigate Fear of Fireworks in Dogs? A Study on the Behavioural and Physiological Effects of a Psychoactive Supplement.Save — Animals : an open access journal from MDPI (2024) · Journal Article
- Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?Save — Journal of ethnopharmacology (2019) · Journal Article; Review
UNCLASSIFIED
Pau d'arco
low confidenceOverallC
Cited studies (2)
- Selective activity of Tabebuia avellanedae against Giardia duodenalis infecting organoid-derived human gastrointestinal epithelia.Save — International journal for parasitology. Drugs and drug resistance (2025) · Journal Article; Research Support, Non-U.S. Gov't
- Comparative metabolism study of β-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry.Save — Journal of pharmaceutical and biomedical analysis (2013) · Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Pea Flour
Also: Pea Flour
low confidenceOverallC
probiotic
Pediococcus acidilactici
low confidenceOverallC
Cited studies (3)
- Natural Endotoxemia in Dogs-A Hidden Condition That Can Be Treated with a Potential Probiotic Containing Bacillus subtilis, Bacillus licheniformis and Pediococcus acidilactici: A Study Model.Save — Animals : an open access journal from MDPI (2021) · Journal Article
- Complete genome sequence of Pediococcus acidilactici CACC 537 isolated from canine.Save — Journal of animal science and technology (2023) · Journal Article
- Pediococcus acidilactici PA-1 Alleviates Diet-Induced Obesity by Modulating Hepatic Amino Acid Metabolism and Gut Microbiota in Mice.Save — Probiotics and antimicrobial proteins (2026) · Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Phosphorus
Also: Phosphorus
low confidenceOverallC
UNCLASSIFIED
Phytoplankton Blend
low confidenceOverallC
Ingredient
Potassium Chloride
Also: Potassium Chloride
low confidenceOverallC
Cited studies (3)
- Effect of tetramethylammonium and potassium chloride on adrenal 17-hydroxycorticosteroid secretion in unanesthetized dogs.Save — The Tohoku journal of experimental medicine (1965) · Journal Article
- Effects of potassium chloride concentration on protein content and polyphenylalanine synthesizing capability of 40S ribosomal subunits from canine pancreas.Save — Biochemistry (1980) · Journal Article; Research Support, U.S. Gov't, P.H.S.
- Oxygen consumption of the nonworking and potassium chloride-arrested dog heart.Save — Circulation research (1980) · Journal Article
Ingredient
Potassium Iodide
Also: Potassium Iodide
low confidenceOverallC
Cited studies (3)
- Purification of the sodium- and potassium-dependent adenosine triphosphatase from canine renal medulla.Save — The Journal of biological chemistry (1971) · Journal Article
- POTASSIUM, SODIUM, AND IODIDE TRANSCAPILLARY EXCHANGE IN THE DOG HEART.Save — The American journal of physiology (1965) · Journal Article
- Serum diiodotyrosine.Save — The Journal of clinical endocrinology and metabolism (1975) · Journal Article
Ingredient
Powdered Cellulose
Also: Powdered Cellulose
low confidenceOverallC
gut
Prebiotic Fibre (Inulin/FOS)
low confidenceOverallC
Compare Claim Grade
Improves faecal microbiome diversity
Short-chain FOS/inulin evidence is largely surrogate-marker based.
View studies & products →
CSave
UNCLASSIFIED
Proprietary Multi Strain Probiotic Blend
low confidenceOverallC
Cited studies (1)
- Antimicrobial effects of four different probiotic compositions and delivery forms on clear aligner biofilm: A randomized single-blind crossover trial.Save — Journal of the World federation of orthodontists (2026) · Journal Article; Randomized Controlled Trial
UNCLASSIFIED
Proprietary probiotic blend
low confidenceOverallC
Cited studies (1)
- Dietary supplementation with fiber, "biotics," and spray-dried plasma affects apparent total tract macronutrient digestibility and the fecal characteristics, fecal microbiota, and immune function of adult dogs.Save — Journal of animal science (2022) · Journal Article
Ingredient
protease
Also: protease
low confidenceOverallC
Cited studies (3)
- Carboxypeptidase A3 expression in canine mast cell tumors and tissue-resident mast cells.Save — Veterinary pathology (2022) · Journal Article; Research Support, Non-U.S. Gov't
- Proteases and Abdominal Pain-Old Dog, New (Microbial) Tricks.Save — Cellular and molecular gastroenterology and hepatology (2026) · Journal Article; Review
- Proteases as prognostic markers in human and canine cancers.Save — Veterinary and comparative oncology (2017) · Journal Article; Review
Ingredient
Psyllium Husk
Also: Psyllium Husk
low confidenceOverallC
Ingredient
Pyridoxine HCL (B6)
Also: Pyridoxine HCL (B6)
low confidenceOverallC
Cited studies (2)
- The vitamin B6 group; comparative growth and anti-anemic potencies of pyridoxal, pyridoxamine and pyridoxine for dogs.Save — Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (1946) · Journal Article
- A history of the isolation and identification of vitamin B(6).Save — Annals of nutrition & metabolism (2012) · Historical Article; Journal Article; Review
Ingredient
Pyridoxine Hydrochloride
Also: Pyridoxine Hydrochloride
low confidenceOverallC
Cited studies (3)
- Use of pyridoxine hydrochloride in the interruption of lactation in female dogs with pseudopregnancy.Save — Animal reproduction (2021) · Journal Article
- Subacute toxicity of pyridoxine hydrochloride in the beagle dog.Save — Toxicology and applied pharmacology (1978) · Journal Article
- A history of the isolation and identification of vitamin B(6).Save — Annals of nutrition & metabolism (2012) · Historical Article; Journal Article; Review
polyphenol
Quercetin
low confidenceOverallC
whole food
Raspberry
low confidenceOverallC
mushroom
Reishi
Also: Ganoderma lucidum
low confidenceOverallC
Compare Claim Grade
General immune modulation
Mostly in-vitro and rodent data; canine outcome data limited.
View studies & products →
CSave
Cited studies (1)
- Antifibrotic action of medicinal mushrooms Ganoderma lucidum and Polyporus umbellatus in MDCK and CRFK cells.Save — Veterinary research communications (2026) · Journal Article
Ingredient
Riboflavin Supplement
Also: Riboflavin Supplement
low confidenceOverallC
Cited studies (3)
- A history of the isolation and identification of vitamin B(6).Save — Annals of nutrition & metabolism (2012) · Historical Article; Journal Article; Review
- Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and other Naturally Occurring Compounds, Part I.Save — Annals of clinical case reports (2022) · Journal Article
- Isolation, identification and selection of beneficial canine homologous lactic acid bacteria by their potential probiotic characteristics.Save — Veterinary research communications (2025) · Journal Article
mushroom
Shiitake
low confidenceOverallC
Ingredient
Silicon
Also: Silicon
low confidenceOverallC
Cited studies (2)
- Retinomorphic image processing.Save — Progress in brain research (2008) · Journal Article; Review
- 2023 AAHA Senior Care Guidelines for Dogs and Cats.Save — Journal of the American Animal Hospital Association (2023) · Journal Article
Ingredient
Silybin A+B
Also: Silybin A+B
low confidenceOverallC
botanical
Slippery Elm Bark
low confidenceOverallC
UNCLASSIFIED
Slippery Elm Bark
low confidenceOverallC
Cited studies (2)
- Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study.Save — Journal of alternative and complementary medicine (New York, N.Y.) (2010) · Clinical Trial; Journal Article
- Ulmus macrocarpa Hance extract modulates intestinal microbiota in healthy adults: a randomized, placebo-controlled clinical trial.Save — Journal of microbiology (Seoul, Korea) (2021) · Journal Article; Randomized Controlled Trial
Ingredient
Sodium Borate
Also: Sodium Borate
low confidenceOverallC
Ingredient
Sodium Molybdate
Also: Sodium Molybdate
low confidenceOverallC
Cited studies (1)
- [Comparative study of the effect of sodium molybdate, tungstate and metavanadate on the electrocardiogram of chloralosed dogs].Save — Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression (1967) · Comparative Study; Journal Article
Ingredient
Sodium Selenite
Also: Sodium Selenite
low confidenceOverallC
Cited studies (3)
- Investigation of the protective effects of different forms of selenium in freezing dog semen: Comparison of nanoparticle selenium and sodium selenite.Save — Reproduction in domestic animals = Zuchthygiene (2024) · Journal Article; Comparative Study
- [SODIUM SELENITE POISONING].Save — Tijdschrift voor gastro-enterologie (1964) · Journal Article
- Optimizing the Adipogenic Induction Protocol Using Rosiglitazone Improves the Physiological Parameters and Differentiation Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells for Horses, Sheep, Dogs, Murines, and Humans.Save — Animals : an open access journal from MDPI (2023) · Journal Article
botanical
Spirulina
low confidenceOverallC
Cited studies (3)
- Oral Palatability and Owners' Perception of the Effect of Increasing Amounts of Spirulina (Arthrospira platensis) in the Diet of a Cohort of Healthy Dogs and Cats.Save — Animals : an open access journal from MDPI (2023) · Journal Article
- Supplementation of Diets With Spirulina Influences Immune and Gut Function in Dogs.Save — Frontiers in nutrition (2021) · Journal Article
- Effect of a weight loss diet with or without Spirulina supplementation on serum lipids and antioxidant capacity of overweight dogs.Save — Scientific reports (2024) · Journal Article
UNCLASSIFIED
Spirulina platensis
low confidenceOverallC
botanical
Stinging Nettle
low confidenceOverallC
Cited studies (3)
- Levels of some microelements and essential heavy metals in herbal teas in Serbia.Save — Acta poloniae pharmaceutica (2014) · Journal Article; Research Support, Non-U.S. Gov't
- Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes.Save — Evidence-based complementary and alternative medicine : eCAM (2012) · Journal Article
- Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?Save — Journal of ethnopharmacology (2019) · Journal Article; Review
probiotic
Streptococcus thermophilus
low confidenceOverallC
Cited studies (3)
- Antimutagenic properties of lactic acid-cultured milk on chemical and fecal mutagens.Save — Journal of dairy science (1986) · Journal Article; Research Support, Non-U.S. Gov't
- Safety and efficacy of a feed additive consisting of Enterococcus faecium NBIMCC 8270, Lactobacillus acidophilus NBIMCC 8242, Lactobacillus helveticus NBIMCC 8269, Lactobacillus delbrueckii ssp. lactis NBIMCC 8250, L. delbrueckii ssp. bulgaricus NBIMCC 8244 and Streptococcus thermophilus NBIMCC 8253 (Probiotic Lactina®) for cats and dogs (Lactina Ltd.).Save — EFSA journal. European Food Safety Authority (2022) · Journal Article
- Functionality and Palatability of Yogurt Produced Using Beetroot Pomace Flour Granulated with Lactic Acid Bacteria.Save — Foods (Basel, Switzerland) (2021) · Journal Article
Ingredient
sucrase
Also: sucrase
low confidenceOverallC
excipient
Sunflower Lecithin
low confidenceOverallC
Ingredient
Tapioca Starch
Also: Tapioca Starch
low confidenceOverallC
Cited studies (1)
- Effects of a Protocol Combining a Non-Irritating Shampoo and an Adelmidrol-Based Adsorbent Mousse on Seborrhoea and Other Signs and Symptoms Secondary to Canine Atopic Dermatitis: A Multicenter, Open-Label Uncontrolled Clinical Trial.Save — Veterinary sciences (2024) · Journal Article
Ingredient
Taurine
Also: Taurine
low confidenceOverallC
Cited studies (3)
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
- Recent Advances in the Nutrition and Metabolism of Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
- Roles of Nutrients in the Brain Development, Cognitive Function, and Mood of Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
Ingredient
Thiamine hydrochloride (B1)
Also: Thiamine hydrochloride (B1)
low confidenceOverallC
Ingredient
Thiamine Mononitrate
Also: Thiamine Mononitrate
low confidenceOverallC
Cited studies (3)
- Thiamine deficiency in dogs and cats.Save — Journal of the American Veterinary Medical Association (2013) · Journal Article; Research Support, Non-U.S. Gov't
- Magnetic resonance imaging pattern recognition of metabolic and neurodegenerative encephalopathies in dogs and cats.Save — Frontiers in veterinary science (2024) · Journal Article
- The immunomodulatory effects of vitamins in cancer.Save — Frontiers in immunology (2024) · Journal Article; Review
Ingredient
Total EPA and DHA
Also: Total EPA and DHA
low confidenceOverallC
Cited studies (2)
- Assessing functional properties of diet protein hydrolysate and oil from fish waste on canine immune parameters, cardiac biomarkers, and fecal microbiota.Save — Frontiers in veterinary science (2024) · Journal Article
- The Supplementation of Docosahexaenoic Acid-Concentrated Fish Oil Enhances Cognitive Function in Puppies.Save — Animals : an open access journal from MDPI (2023) · Journal Article
mushroom
Turkey Tail
Also: Trametes versicolor, PSK, PSP
low confidenceOverallC
Compare Claim Grade
Extended survival in canine hemangiosarcoma (small study)
Single small trial (Brown 2012, PSK 100 mg/kg); results have not been replicated at scale.
View studies & products →
CSave
Cited studies (2)
- Polysaccharopeptide (PSP) from Turkey Tail in canine hemangiosarcoma Save — Evidence-Based Complementary and Alternative Medicine (2012) · pilot RCT
- Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcomaSave — Evidence-Based Complementary and Alternative Medicine (2012) · RCT
botanical
Turmeric / Curcumin
Also: Turmeric, Curcuma longa
low confidenceOverallC
Limited canine combination-product evidence exists; unstandardized turmeric root powder is not equivalent to a quantified curcuminoid extract.
Compare Claim Grade
Adjunctive anti-inflammatory effect in canine OA
Bioavailability is the main limit; results are mixed and formulation-dependent.
View studies & products →
CSave
Cited studies (4)
- Bioavailable curcumin formulation in canine OA Save — Canadian Journal of Animal Science (2016) · RCT
- Turmeric and Curcumin-Health-Promoting Properties in Humans versus Dogs.Save — International journal of molecular sciences (2023) · Journal Article; Review
- Antitumor Effect of Curcumin, D6 Turmeric, and Hydrochloride Mitoxantrone on Canine and Human Urothelial Cancer Cells.Save — Animals : an open access journal from MDPI (2025) · Journal Article
- Effects and synergy of feed ingredients on canine neoplastic cell proliferation.Save — BMC veterinary research (2016) · Journal Article
Ingredient
Vitamin A Palmitate
Also: Vitamin A Palmitate
low confidenceOverallC
Cited studies (3)
- Blood vitamin levels in dogs with chronic kidney disease.Save — Veterinary journal (London, England : 1997) (2012) · Journal Article; Research Support, Non-U.S. Gov't
- Retinol and retinyl ester responses in the blood plasma and urine of dogs after a single oral dose of vitamin A.Save — The Journal of nutrition (2002) · Journal Article; Research Support, Non-U.S. Gov't
- Levels of retinol and retinyl esters in plasma and urine of dogs with urolithiasis.Save — Journal of veterinary medicine. A, Physiology, pathology, clinical medicine (2003) · Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Vitamin B2 (riboflavin)
Also: Vitamin B2 (riboflavin)
low confidenceOverallC
Ingredient
Vitamin B3 (niacin)
Also: Vitamin B3 (niacin)
low confidenceOverallC
Ingredient
Vitamin B6 (pyridoxine)
Also: Vitamin B6 (pyridoxine)
low confidenceOverallC
vitamin
Vitamin C
low confidenceOverallC
Cited studies (3)
- Metabolic disease in animals.Save — Seminars in musculoskeletal radiology (2002) · Journal Article; Review
- Recent Advances in the Nutrition and Metabolism of Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
- Characteristics of Nutrition and Metabolism in Dogs and Cats.Save — Advances in experimental medicine and biology (2024) · Journal Article
UNCLASSIFIED
Water
low confidenceOverallC
Cited studies (1)
- C-LTMRs evoke wet dog shakes via the spinoparabrachial pathway.Save — Science (New York, N.Y.) (2024) · Journal Article; Research Support, N.I.H., Extramural
Ingredient
Wheat Grass
Also: Wheat Grass
low confidenceOverallC
Cited studies (3)
- Canine hysteria and wheat.Save — Lancet (London, England) (1948) · Journal Article
- Extract and molecular-based early infant sensitization and associated factors-A PreventADALL study.Save — Allergy (2021) · Journal Article; Research Support, Non-U.S. Gov't
- Response to Hansen Wheat et al.: Additional analysis further supports the early emergence of cooperative communication in dogs compared to wolves raised with more human exposure.Save — Learning & behavior (2023) · Editorial; Comment
Ingredient
Whey Protein
Also: Whey Protein
low confidenceOverallC
Ingredient
Yucca Root
Also: Yucca Root
low confidenceOverallC
Cited studies (1)
- Enhanced gut microbiome supplementation of essential amino acids in Diploptera punctata fed low-protein plant-based diet.Save — Frontiers in insect science (2024) · Journal Article
Ingredient
Zinc Citrate
Also: Zinc Citrate
low confidenceOverallC
Cited studies (3)
- Efficacy of zinc citrate ascorbate for treatment of canine cataracts.Save — Journal of the American Veterinary Medical Association (1989) · Journal Article; Research Support, Non-U.S. Gov't
- Renal tubular handling of zinc in the dog.Save — The American journal of physiology (1981) · Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
- Influence of the Addition of Zinc Oxide Nanoparticles to Cryopreservation Medium for Dog Epididymal Spermatozoa.Save — Topics in companion animal medicine (2023) · Journal Article
Ingredient
Zinc Proteinate
Also: Zinc Proteinate
low confidenceOverallC
Cited studies (2)
- Effect of Zinc Source and Exogenous Enzymes Supplementation on Zinc Status in Dogs Fed High Phytate Diets.Save — Animals : an open access journal from MDPI (2020) · Journal Article
- Effects of Zinc Source and Enzyme Addition on the Fecal Microbiota of Dogs.Save — Frontiers in microbiology (2021) · Journal Article
Ingredient
Zinc Sulfate
Also: Zinc Sulfate
low confidenceOverallC
homeopathic
Aconitum napellus 200C (homeopathic)
Also: Aconite 200C
low confidenceOverallD
No reliable canine clinical evidence supports Aconite 200C for fear, shock, pain, inflammation or injury.
Ingredient
Ahiflower seed oil
Also: Ahiflower seed oil
low confidenceOverallD
Cited studies (2)
- Can Ahiflower® (Buglossoides arvensis) seed-oil supplementation help overcome the adverse effects of imidacloprid in honey bees?Save — Comparative biochemistry and physiology. Toxicology & pharmacology : CBP (2025) · Journal Article
- Consumption of Buglossoides arvensis seed oil is safe and increases tissue long-chain n-3 fatty acid content more than flax seed oil - results of a phase I randomised clinical trial.Save — Journal of nutritional science (2016) · Journal Article
botanical
Aloe Vera Leaf
low confidenceOverallD
homeopathic
Arnica montana 200C (homeopathic)
Also: Arnica 200C
low confidenceOverallD
Systematic review evidence does not support homeopathic Arnica as more effective than placebo.
botanical
Burdock Root
low confidenceOverallD
Ingredient
Calcium Ascorbate
Also: Calcium Ascorbate
low confidenceOverallD
UNCLASSIFIED
Cellulase (trichoderma longibrachiatum)
low confidenceOverallD
Cited studies (1)
- Effects of exogenous cellulase supplementation on microbial growth and ruminal fermentation of a high-forage diet in Rusitec fermenters.Save — Journal of animal science (2007) · Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
Ingredient
Copper Proteinate
Also: Copper Proteinate
low confidenceOverallD
Cited studies (2)
- Copper metabolism of holstein and jersey cows and heifers fed diets high in cupric sulfate or copper proteinate.Save — Journal of dairy science (1996) · Journal Article; Research Support, Non-U.S. Gov't
- Optimal dietary copper requirements and relative bioavailability for weanling pigs fed either copper proteinate or tribasic copper chloride.Save — Journal of animal science and biotechnology (2020) · Journal Article
mineral
Diatomaceous Earth (Food Grade)
low confidenceOverallD
Ingredient
Dried Shellfish Digest
Also: Dried Shellfish Digest
low confidenceOverallD
Cited studies (1)
- Effects of dietary Pediococcus acidilactici GY2 single or combined with Saccharomyces cerevisiae or/and β-glucan on the growth, innate immunity response and disease resistance of Macrobrachium rosenbergii.Save — Fish & shellfish immunology (2020) · Journal Article
botanical
Fennel
low confidenceOverallD
botanical
Flax Seed Meal
low confidenceOverallD
Cited studies (2)
- Evaluating the impact of organic chromium with flax seed in broiler diets: effects on production performance, breast muscle pathology, and meat quality aspects.Save — Poultry science (2023) · Journal Article
- Flaxseed.Save — (2006) · Review
mineral
Fulvic Acid
low confidenceOverallD
botanical
Goldenseal
low confidenceOverallD
Ingredient
Gut Soothe
Also: Gut Soothe
low confidenceOverallD
Cited studies (2)
- Effects of supplemental feeding of Chinese herbal mixtures to perinatal sows on antioxidant capacity and gut microbiota of sows and their offspring piglets.Save — Frontiers in microbiology (2024) · Journal Article
- Tong Xie Yao Fang: A Classic Chinese Medicine Prescription with Potential for the Treatment of Ulcerative Colitis.Save — Evidence-based complementary and alternative medicine : eCAM (2021) · Journal Article; Review
other
Hemp Protein
low confidenceOverallD
Cited studies (3)
- The Endocannabinoid System of Animals.Save — Animals : an open access journal from MDPI (2019) · Journal Article; Review
- Current review of hemp-based medicines in dogs.Save — Journal of veterinary pharmacology and therapeutics (2021) · Journal Article; Review
- Cats and cannabinoids: past, present and future.Save — Journal of feline medicine and surgery (2025) · Journal Article; Review
animal
Herring Oil (EPA/DHA)
low confidenceOverallD
mineral
Humic Acid
low confidenceOverallD
Ingredient
Iodine
Also: Iodine
low confidenceOverallD
botanical
Irish Moss
low confidenceOverallD
whole food
Kale
low confidenceOverallD
vitamins
Kelp
low confidenceOverallD
Compare Claim Grade
Source of iodine and trace minerals
Iodine content is highly variable batch-to-batch; risk of over-supplementation.
View studies & products →
DSave
Ingredient
lipase
Also: lipase
low confidenceOverallD
Cited studies (3)
- Advances in the diagnosis of acute pancreatitis in dogs.Save — Journal of veterinary internal medicine (2021) · Journal Article; Review
- Diagnosis of pancreatitis in dogs and cats.Save — The Journal of small animal practice (2015) · Journal Article; Review
- A review: Pancreatic enzymes in the treatment of chronic pancreatic insufficiency in companion animals.Save — Journal of veterinary internal medicine (2024) · Journal Article; Review
Ingredient
Magnesium ascorbate
Also: Magnesium ascorbate
low confidenceOverallD
Cited studies (3)
- Nutrition and bone disease in the dog and cat.Save — The Veterinary record (1976) · Journal Article; Review
- Vitamin C in Health and Disease: A Companion Animal Focus.Save — Topics in companion animal medicine (2020) · Journal Article; Review
- Vitamin C and lifespan in model organisms.Save — Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2013) · Journal Article; Research Support, Non-U.S. Gov't; Review
Ingredient
Manganese Proteinate
Also: Manganese Proteinate
low confidenceOverallD
Cited studies (2)
- Dietary manganese supplementation decreases hepatic lipid deposition by regulating gene expression and enzyme activity involved in lipid metabolism in the liver of broilers.Save — Journal of animal science (2024) · Journal Article
- Relative bioavailability of manganese in relation to proteinate and sulfate sources for broiler chickens from one to 20 d of age.Save — Poultry science (2020) · Journal Article
botanical
Marshmallow Root
low confidenceOverallD
Ingredient
Menadione Sodium Bisulfite Complex
Also: Menadione Sodium Bisulfite Complex
low confidenceOverallD
Ingredient
Natural Flavoring
Also: Natural Flavoring
low confidenceOverallD
Cited studies (1)
- Additives in pet food: are they safe?Save — The Journal of small animal practice (2021) · Journal Article; Review
botanical
Nettle Leaf
low confidenceOverallD
UNCLASSIFIED
Nettle Leaf Powder
low confidenceOverallD
Cited studies (2)
- Nettle (Urtica dioica) supplementation: impact on growth, hematology, immune response, and resilience to Aeromonas hydrophila in Labeo rohita fingerlings.Save — Veterinary research communications (2024) · Journal Article
- Evaluating the effect of a herb on the control of blood glucose and insulin-resistance in patients with advanced type 2 diabetes (a double-blind clinical trial).Save — Caspian journal of internal medicine (2020) · Journal Article
Ingredient
Omega-3 Fatty Acids
Also: Omega-3 Fatty Acids
low confidenceOverallD
Ingredient
Omega-6 Fatty Acids
Also: Omega-6 Fatty Acids
low confidenceOverallD
UNCLASSIFIED
Organic cordyceps mushroom extract
low confidenceOverallD
Cited studies (2)
- Anti-Allergic Effects of Dietary Caterpillar Mushroom Cordyceps militaris (Ascomycota) Derived from Eri Silkworm.Save — International journal of medicinal mushrooms (2025) · Journal Article
- Supercritical Carbon Dioxide Extracts of Cordyceps sinensis: Chromatography-based Metabolite Profiling and Protective Efficacy Against Hypobaric Hypoxia.Save — Frontiers in pharmacology (2021) · Journal Article
UNCLASSIFIED
Organic milk thistle seed
low confidenceOverallD
Cited studies (1)
- Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial.Save — Frontiers in nutrition (2026) · Journal Article
UNCLASSIFIED
Organic olive leaf
low confidenceOverallD
UNCLASSIFIED
Organic reishi mushroom extract
low confidenceOverallD
Cited studies (2)
- Ganoderma lucidum Mycelia Mass and Bioactive Compounds Production through Grape Pomace and Cheese Whey Valorization.Save — Molecules (Basel, Switzerland) (2023) · Journal Article
- The effects of bitter melon (Momordica charantia) on serum and liver triglyceride levels in rats.Save — Journal of ethnopharmacology (2004) · Journal Article; Research Support, Non-U.S. Gov't
UNCLASSIFIED
Organic Silybum Marianum (Milk thistle)
low confidenceOverallD
Cited studies (1)
- Effectiveness and safety of an ayurvedic nutraceutical for improving clinical parameters of liver function in participants with metabolic dysfunction-associated steatotic liver disease: a randomized, placebo-controlled, preliminary phase 2 exploratory clinical trial.Save — Frontiers in nutrition (2026) · Journal Article
Ingredient
Organic Spinach
Also: Organic Spinach
low confidenceOverallD
Cited studies (1)
- Antibacterial, antiviral, and antifungal properties of wines and winery byproducts in relation to their flavonoid content.Save — Journal of agricultural and food chemistry (2014) · Journal Article; Review
Ingredient
Organic Sunflower Seeds
Also: Organic Sunflower Seeds
low confidenceOverallD
UNCLASSIFIED
Organic thyme leaf
low confidenceOverallD
UNCLASSIFIED
Organic turkey tail mushroom extract
low confidenceOverallD
UNCLASSIFIED
Organic wild blueberries
low confidenceOverallD
Cited studies (2)
- Vaccinium uliginosum and Vaccinium myrtillus-Two Species-One Used as a Functional Food.Save — Nutrients (2023) · Journal Article; Review
- Effects of wild blueberry (Vaccinium angustifolium) pomace feeding on gut microbiota and blood metabolites in free-range pastured broiler chickens.Save — Poultry science (2019) · Journal Article
botanical
Parsley
low confidenceOverallD
botanical
Pau d'Arco
low confidenceOverallD
mushroom
Phellinus
low confidenceOverallD
Ingredient
Pollock Oil
Also: Pollock Oil
low confidenceOverallD
Cited studies (2)
- Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet.Save — Lipids in health and disease (2011) · Journal Article
- Possible effects of pollock and herring on the growth and reproductive success of Steller sea lions (Eumetopias jubatus): insights from feeding experiments using an alternative animal model, Rattus norvegicus.Save — The British journal of nutrition (2003) · Journal Article; Research Support, Non-U.S. Gov't
mushroom
Poria Cocos
low confidenceOverallD
UNCLASSIFIED
Prebiotic Larch Arabinogalactan
low confidenceOverallD
Cited studies (1)
- Lactobacilli Supplemented with Larch Arabinogalactan and Colostrum Stimulates an Immune Response towards Peripheral NK Activation and Gut Tolerance.Save — Nutrients (2020) · Journal Article
UNCLASSIFIED
Purified silver 10 ppm (parts per million)
low confidenceOverallD
UNCLASSIFIED
Ruta
low confidenceOverallD
other
Saccharomyces cerevisiae Yeast (MicroBuild)
low confidenceOverallD
Cited studies (3)
- Dietary activators of Sirt1.Save — Molecular and cellular endocrinology (2009) · Journal Article; Research Support, N.I.H., Intramural; Review
- GCN2, an old dog with new tricks.Save — Biochemical Society transactions (2013) · Journal Article; Research Support, Non-U.S. Gov't; Review
- Where and Why Modeling Amyotrophic Lateral Sclerosis.Save — International journal of molecular sciences (2021) · Journal Article; Review
homeopathic
Sulphur
low confidenceOverallD
UNCLASSIFIED
Symphytum
low confidenceOverallD
Ingredient
Tapioca Flour
Also: Tapioca Flour
low confidenceOverallD
botanical
Thyme Leaf
low confidenceOverallD
botanical
Valerian Root
low confidenceOverallD
mineral
Zinc (Proteinate/Citrate)
low confidenceOverallD
Cited studies (1)
- Effects of dietary copper concentration and source on performance and copper status of growing and finishing steers.Save — Journal of animal science (2000) · Journal Article

Compare	Claim	Grade
	Comparable OA benefit to fish oil per mg EPA+DHA Small trials show similar outcomes; higher cost per mg omega-3 in Canada. View studies & products →	BSave

Compare	Claim	Grade
	Essential for bone, immune and cardiac health Deficiency and excess both harmful; supplement only when a diet is measured-deficient. View studies & products →	ASave

Compare	Claim	Grade
	Anti-inflammatory / odour-reduction claims Mostly in-vitro and anecdotal; safety concerns at high doses. View studies & products →	DSave

Compare	Claim	Grade
	Adds modest benefit when combined with glucosamine Best evidence is combined formulations; monotherapy data are weaker. View studies & products →	BSave

Compare	Claim	Grade
	Anti-inflammatory joint benefit in dogs Active omega-3 responsible for most of the OA effect; dose reported per EPA content. View studies & products →	ASave

Compare	Claim	Grade
	Reduces mild-to-moderate OA signs in dogs Meta-analyses show a small but real benefit; effect is smaller than NSAIDs and slower to onset. View studies & products →	BSave

Compare	Claim	Grade
	Reduces OA pain and joint swelling Several canine trials support use at ~30 mg/kg/day of stabilised powder. View studies & products →	BSave

Compare	Claim	Grade
	General gut and immune support Effects depend on strain identity, CFU at expiry, and delivery survival. View studies & products →	BSave

Compare	Claim	Grade
	Reduces dental plaque and calculus in dogs Multiple RCTs on the ProDen PlaqueOff strain show plaque/tartar reduction. View studies & products →	BSave

Compare	Claim	Grade
	Reduces acute and antibiotic-associated diarrhoea in dogs Randomised canine data support use for AAD and stress diarrhoea. View studies & products →	BSave

Compare	Claim	Grade
	Same benefits as fish oil at label EPA/DHA dose Bioequivalent when EPA+DHA dose is matched; sourcing and freshness matter more than species. View studies & products →	ASave

Compare	Claim	Grade
	Hepatoprotective; helps in copper and steroid hepatopathy Multiple canine studies support use, often combined with silybin. View studies & products →	BSave

Compare	Claim	Grade
	Improves lameness scores comparable to glucosamine+chondroitin Small canine RCTs (40 mg/day) show improvement in force-plate and owner scores. View studies & products →	BSave

Compare	Claim	Grade
	Antioxidant support especially with high PUFA diets Requirement rises with fish/omega-3 intake. View studies & products →	BSave

Compare	Claim	Grade
	Reduces stress-associated diarrhoea (strain AHC7) Strain-specific canine RCTs support this; not all Bifido products are equivalent. View studies & products →	BSave

Compare	Claim	Grade
	Palatability, hydration and modest gelatin/amino acid content No strong disease-modifying evidence; safe when made without onion/garlic/excess salt. View studies & products →	CSave

Compare	Claim	Grade
	Adjunct in canine cardiomyopathy Small canine data; often used empirically alongside standard cardiology treatment. View studies & products →	CSave

Compare	Claim	Grade
	Modulates immune and gut markers Small studies; effect sizes modest and variable by source. View studies & products →	CSave

Compare	Claim	Grade
	Meaningful benefit only in EPI-diagnosed dogs Otherwise limited benefit in normal dogs on complete diets. View studies & products →	CSave

Compare	Claim	Grade
	Palatability and moisture-free convenience Nutritional benefit depends on the base diet; pathogen risk exists in raw formats. View studies & products →	CSave

Compare	Claim	Grade
	Palatability and probiotic delivery (if raw/fermented) Modest evidence for tolerance vs cow milk; not a meaningful nutrient source. View studies & products →	CSave

Compare	Claim	Grade
	Reduces situational anxiety in dogs Open-label and small blinded studies suggest benefit for storm/travel anxiety. View studies & products →	CSave

Compare	Claim	Grade
	Improves stool quality in healthy dogs Strain-specific; general genus claims are weak. View studies & products →	CSave

Compare	Claim	Grade
	Cognitive and nerve-growth-factor support Rodent and human pilot data; no controlled canine trials yet. View studies & products →	CSave

Compare	Claim	Grade
	Aids sleep and reduces noise-phobia signs Mostly clinical experience and small case series; behavioural plan should be first-line. View studies & products →	CSave

Compare	Claim	Grade
	Hepatoprotective adjunct for liver disease Silybin-phosphatidylcholine complexes have the best pharmacokinetic data in dogs. View studies & products →	CSave

Compare	Claim	Grade
	Adjunctive OA pain relief Mostly extrapolated from human OA trials; limited dog-specific RCTs. View studies & products →	CSave

Compare	Claim	Grade
	Improves faecal microbiome diversity Short-chain FOS/inulin evidence is largely surrogate-marker based. View studies & products →	CSave

Compare	Claim	Grade
	General immune modulation Mostly in-vitro and rodent data; canine outcome data limited. View studies & products →	CSave

Compare	Claim	Grade
	Extended survival in canine hemangiosarcoma (small study) Single small trial (Brown 2012, PSK 100 mg/kg); results have not been replicated at scale. View studies & products →	CSave

Compare	Claim	Grade
	Adjunctive anti-inflammatory effect in canine OA Bioavailability is the main limit; results are mixed and formulation-dependent. View studies & products →	CSave

Compare	Claim	Grade
	Source of iodine and trace minerals Iodine content is highly variable batch-to-batch; risk of over-supplementation. View studies & products →	DSave

Educational information only. Not veterinary advice. Always talk to your vet before starting a new supplement.