Paw Privileges
Evidence DatabaseSaved evidence
Claim evidence

Adds modest benefit when combined with glucosamine

Grade BSolid canine or strong extrapolated evidenceSave claim
Ingredient: Chondroitin Sulfate · joint

Plain-language summary

Best evidence is combined formulations; monotherapy data are weaker.

About the ingredient

What it is

Glycosaminoglycan found in cartilage.

Why it's used

Paired with glucosamine in joint formulas.

Also known as: Chondroitin

Cited studies (5)

Canine studies
  • Corrigendum: Study of the effectiveness of glucosamine and chondroitin sulfate, marine based fatty acid compounds (PCSO-524 and EAB-277), and carprofen for the treatment of dogs with hip osteoarthritis: a prospective, block-randomized, double-blinded, placebo-controlled clinical trial.
    Kampa N, Kaenkangploo D, Jitpean S, Srithunyarat T, Seesupa S, Hoisang S, Yongvanit K, Kamlangchai P, Tuchpramuk P, Lascelles BDX · Frontiers in veterinary science · 2023
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Published Erratum
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Chondroitin Sulfate

    DOI: 10.3389/fvets.2023.1252778
  • Chondroitin sulfate in canine OA — systematic review
    Veterinary Anaesthesia and Analgesia · 2018
    Save studyB
    Study summary
    Limited quality
    Design score 5/11
    Design
    systematic review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Systematic review of multiple studies
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Outcome: Combined joint supplements outperform mono-agents

  • GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
    Pickart L, Vasquez-Soltero JM, Margolina A · BioMed research international · 2015
    Save studyD
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Chondroitin Sulfate

    DOI: 10.1155/2015/648108
  • Chondroitin sulfate proteoglycan-4: a biomarker and a potential immunotherapeutic target for canine malignant melanoma.
    Mayayo SL, Prestigio S, Maniscalco L, Rosa G, Aricò A, Maria R, Cavallo F, Ferrone S, Buracco P, Iussich S · Veterinary journal (London, England : 1997) · 2011
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Chondroitin Sulfate

    DOI: 10.1016/j.tvjl.2011.02.020
  • Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis
    McCarthy G, O'Donovan J, Jones B, McAllister H, Seed M, Mooney C · The Veterinary Journal · 2007
    Save studyB
    Study summary
    Moderate quality
    Design score 6/11
    Design
    RCT
    Species
    DOG
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Randomized control group · DOUBLE
    Funding
    Not reported
    Dose studied: 475 mg glucosamine + 350 mg chondroitin per 25 kg/day
    Strengths
    • Randomized trial design
    • Conducted in dogs
    • DOUBLE
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Positive-controlled canine osteoarthritis trial of combined glucosamine/chondroitin.

    DOI: 10.1016/j.tvjl.2006.02.015

Products in our catalog with Chondroitin Sulfate (20)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.