Paw Privileges
Evidence DatabaseSaved evidence
Claim evidence

Extended survival in canine hemangiosarcoma (small study)

Grade CLimited or mixed evidenceSave claim
Ingredient: Turkey Tail · mushroom

Plain-language summary

Single small trial (Brown 2012, PSK 100 mg/kg); results have not been replicated at scale.

About the ingredient

What it is

Medicinal mushroom rich in polysaccharides.

Why it's used

Marketed for immune support.

Also known as: Trametes versicolor, PSK, PSP

Cited studies (5)

Canine studies
  • Behavioral and cognitive animal models in headache research.
    Vuralli D, Wattiez AS, Russo AF, Bolay H · The journal of headache and pain · 2019
    Save studyD
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Turkey Tail

    DOI: 10.1186/s10194-019-0963-6
  • Polysaccharopeptide (PSP) from Turkey Tail in canine hemangiosarcoma
    Evidence-Based Complementary and Alternative Medicine · 2012
    Save studyC
    Study summary
    Moderate quality
    Design score 6/11
    Design
    pilot RCT
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Controlled comparison group (per recorded study design)
    Funding
    Not reported
    Strengths
    • Randomized trial design
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • Study duration not recorded

    Outcome: Median survival extended vs historical controls

  • Single agent polysaccharopeptide delays metastases and improves survival in naturally occurring hemangiosarcoma
    Brown DC, Reetz J · Evidence-Based Complementary and Alternative Medicine · 2012
    Save studyC
    Study summary
    Moderate quality
    Design score 6/11
    Design
    RCT
    Species
    DOG
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Randomized control group · DOUBLE
    Funding
    Not reported
    Dose studied: 25, 50 or 100 mg/kg/day PSP
    Strengths
    • Randomized trial design
    • Conducted in dogs
    • DOUBLE
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Only substantive canine dosing study for turkey tail polysaccharopeptide.

    DOI: 10.1155/2012/384301
  • Atypical antipsychotic drugs and ethanol withdrawal syndrome: a review.
    Uzbay TI · Alcohol and alcoholism (Oxford, Oxfordshire) · 2012
    Save studyD
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Research Support, Non-U.S. Gov't; Review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Turkey Tail

    DOI: 10.1093/alcalc/agr142
  • Comparison of clomipramine and fluoxetine treatment of dogs with tail chasing.
    Yalcin E · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere · 2010
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Turkey Tail

Products in our catalog with Turkey Tail (4)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.