Paw Privileges
Evidence DatabaseSaved evidence
Claim evidence

Adjunctive OA pain relief

Grade CLimited or mixed evidenceSave claim
Ingredient: MSM · joint

Plain-language summary

Mostly extrapolated from human OA trials; limited dog-specific RCTs.

About the ingredient

What it is

Organosulfur compound.

Why it's used

Included in joint-support formulas.

Also known as: Methylsulfonylmethane

Cited studies (3)

Canine studies
  • Digestiblity and metabolisable energy in high-ash poultry meal and plant protein ingredients for dogs.
    de Oliveira LD, Penazzi L, Kawauchi IM, Palumbo GR, de S Theodoro S, Prola L, Carciofi AC · Archives of animal nutrition · 2025
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for MSM

    DOI: 10.1080/1745039X.2025.2584815
  • A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.
    Peric M, Pešić D, Alihodžić S, Fajdetić A, Herreros E, Gamo FJ, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer-Bazaga S, Martínez MS, Gargallo-Viola D, Mathis A, Kessler A, Banjanac M, Padovan J, Bencetić Mihaljević V, Munic Kos V, Bukvić M, Eraković Haber V, Spaventi R · British journal of pharmacology · 2021
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Research Support, Non-U.S. Gov't
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for MSM

    DOI: 10.1111/bph.15292
  • Severe acute respiratory syndrome.
    Nassiri RM · Medical science monitor : international medical journal of experimental and clinical research · 2003
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Editorial
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for MSM

Products in our catalog with MSM (21)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.