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Evidence DatabaseSaved evidence
Claim evidence

Reduces OA pain and joint swelling

Grade BSolid canine or strong extrapolated evidenceSave claim
Ingredient: Green-Lipped Mussel · joint

Plain-language summary

Several canine trials support use at ~30 mg/kg/day of stabilised powder.

About the ingredient

What it is

A marine mollusc native to New Zealand rich in omega-3s and glycosaminoglycans.

Why it's used

Included in joint-support formulas for its anti-inflammatory omega-3 profile.

Also known as: GLM, Perna canaliculus, Green Lipped Mussel

Cited studies (5)

Canine studies
  • Clinical Guide to Obesity and Nonherbal Nutraceuticals in Canine Orthopedic Conditions.
    Ratsch BE, Levine D, Wakshlag JJ · The Veterinary clinics of North America. Small animal practice · 2022
    Save studyD
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Green-Lipped Mussel

    DOI: 10.1016/j.cvsm.2022.03.002
  • The effectiveness of marine based fatty acid compound (PCSO-524) and firocoxib in the treatment of dogs with osteoarthritis
    Vijarnsorn M, Kwananocha I, Kashemsant N, et al. · BMC Veterinary Research · 2019
    Save studyB
    Study summary
    Moderate quality
    Design score 6/11
    Design
    RCT
    Species
    DOG
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Randomized control group · BLINDED_ASSESSOR
    Funding
    Not reported
    Dose studied: PCSO-524 per label, 8 weeks
    Strengths
    • Randomized trial design
    • Conducted in dogs
    • BLINDED_ASSESSOR
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Green-lipped mussel lipid extract compared with an NSAID in canine osteoarthritis.

    DOI: 10.1186/s12917-019-2110-7
  • Comment on "Effects of different omega-3 sources, fish oil, krill oil, and green-lipped mussel against cytokine-mediated canine cartilage degradation" In Vitro Cell Dev Biol Anim. 2017 doi: 10.1007/s11626-016-0125-y.
    Myers SP, Oliver C · In vitro cellular & developmental biology. Animal · 2017
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Letter; Comment
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Green-Lipped Mussel

    DOI: 10.1007/s11626-017-0188-4
  • Green-lipped mussel powder in dogs with osteoarthritis
    Australian Veterinary Journal · 2002
    Save studyB
    Study summary
    Moderate quality
    Design score 6/11
    Design
    RCT
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Controlled comparison group (per recorded study design)
    Funding
    Not reported
    Strengths
    • Randomized trial design
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • Study duration not recorded

    Outcome: Reduced pain and swelling scores

  • Improvement of arthritic signs in dogs fed green-lipped mussel (Perna canaliculus).
    Bierer TL, Bui LM · The Journal of nutrition · 2002
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Research Support, Non-U.S. Gov't
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Green-Lipped Mussel

    DOI: 10.1093/jn/132.6.1634S

Products in our catalog with Green-Lipped Mussel (10)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.