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Claim evidence

Anti-inflammatory joint benefit in dogs

Grade AStrong canine evidenceSave claim
Ingredient: EPA · omega

Plain-language summary

Active omega-3 responsible for most of the OA effect; dose reported per EPA content.

About the ingredient

What it is

A long-chain omega-3 fatty acid.

Why it's used

Supports skin, coat and joint comfort.

Also known as: Eicosapentaenoic acid

Cited studies (4)

Canine studies
  • Exploring the efficacy and optimal dosages of omega-3 supplementation for companion animals.
    Vendramini THA, Marchi PH, Olivindo RFG, Pedrinelli V, Amaral AR, Miranda MS, Príncipe LA, Cesar CGL, Zafalon RVA, Perini MP, Lima LOC, Balieiro JCC, Brunetto MA · Nutrition research reviews · 2025
    Save studyD
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for EPA

    DOI: 10.1017/S0954422425100115
  • Genetic tracing of market wildlife and viruses at the epicenter of the COVID-19 pandemic.
    Crits-Christoph A, Levy JI, Pekar JE, Goldstein SA, Singh R, Hensel Z, Gangavarapu K, Rogers MB, Moshiri N, Garry RF, Holmes EC, Koopmans MPG, Lemey P, Peacock TP, Popescu S, Rambaut A, Robertson DL, Suchard MA, Wertheim JO, Rasmussen AL, Andersen KG, Worobey M, Débarre F · Cell · 2024
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for EPA

    DOI: 10.1016/j.cell.2024.08.010
  • Cyphenothrin (Veterinary Medicinal Products).
    Food Safety Commission of Japan · Food safety (Tokyo, Japan) · 2023
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for EPA

    DOI: 10.14252/foodsafetyfscj.D-23-00008
  • Effect of an EPA-rich diet on ex-vivo cartilage metabolism
    American Journal of Veterinary Research · 2003
    Save studyB
    Study summary
    Very limited quality
    Design score 2/11
    Design
    in vitro
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not applicable (in vitro)
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Lab-dish (in vitro) work, not a live-dog trial
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Outcome: Reduced cartilage aggrecanase activity

Products in our catalog with EPA (3)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.