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Evidence DatabaseSaved evidence
Claim evidence

General immune modulation

Grade CLimited or mixed evidenceSave claim
Ingredient: Reishi · mushroom

Plain-language summary

Mostly in-vitro and rodent data; canine outcome data limited.

About the ingredient

What it is

Medicinal mushroom.

Why it's used

Marketed for immune support.

Also known as: Ganoderma lucidum

Cited studies (3)

Canine studies
  • Antifibrotic action of medicinal mushrooms Ganoderma lucidum and Polyporus umbellatus in MDCK and CRFK cells.
    Gogulski M, Leciejewska N, Nowak M, Juzwik P, Kwiatkowska J, Łozinska M, Sosinski O, Sassek M, Cieślak A, Kołodziejski PA, Pruszyńska-Oszmałek E, Pruszynska-Oszmałek E · Veterinary research communications · 2026
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Reishi

    DOI: 10.1007/s11259-026-11155-x
  • Colon targeting in rats, dogs and IBD patients with species-independent film coatings.
    Ferraro F, Sonnleitner LM, Neut C, Mahieux S, Verin J, Siepmann J, Siepmann F · International journal of pharmaceutics: X · 2024
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Reishi

    DOI: 10.1016/j.ijpx.2024.100233
  • Functional properties of Ganoderma lucidum supplementation in canine nutrition.
    Kayser E, Castaneda PL, Soto-Diaz K, Steelman AJ, Murphy A, Spindola M, He F, de Godoy MRC · Journal of animal science · 2024
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for Reishi

    DOI: 10.1093/jas/skae051

Products in our catalog with Reishi (2)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.