Evidence DatabaseSaved evidence
Claim evidence

Hepatoprotective; helps in copper and steroid hepatopathy

Grade BSolid canine or strong extrapolated evidenceSave claim
Ingredient: SAMe (S-Adenosylmethionine) · liver

Plain-language summary

Multiple canine studies support use, often combined with silybin.

About the ingredient

Cited studies (1)

Canine studies
  • SAMe in dogs with acetaminophen-induced hepatotoxicity
    American Journal of Veterinary Research · 2004
    Save studyB
    Study summary
    Moderate quality
    Design score 6/11
    Design
    RCT
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Controlled comparison group (per recorded study design)
    Funding
    Not reported
    Strengths
    • Randomized trial design
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • Study duration not recorded

    Outcome: Reduced hepatic injury markers

Products in our catalog with SAMe (S-Adenosylmethionine) (1)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.