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Claim evidence

Hepatoprotective; helps in copper and steroid hepatopathy

Grade BSolid canine or strong extrapolated evidenceSave claim
Ingredient: SAMe (S-Adenosylmethionine) · liver

Plain-language summary

Multiple canine studies support use, often combined with silybin.

About the ingredient

Cited studies (4)

Canine studies
  • Nutritional Factors Related to Canine Gallbladder Diseases-A Scoping Review.
    Teixeira FA, Aicher KM, Duarte R · Veterinary sciences · 2024
    Save studyD
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article; Review
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for SAMe (S-Adenosylmethionine)

    DOI: 10.3390/vetsci12010005
  • Treatment and outcomes of dogs with hepatocutaneous syndrome or hepatocutaneous-associated hepatopathy.
    Loftus JP, Miller AJ, Center SA, Peters-Kennedy J, Astor M · Journal of veterinary internal medicine · 2022
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for SAMe (S-Adenosylmethionine)

    DOI: 10.1111/jvim.16323
  • Hepatoprotective effects of S-adenosylmethionine and silybin on canine hepatocytes in vitro.
    Au AY, Hasenwinkel JM, Frondoza CG · Journal of animal physiology and animal nutrition · 2013
    Save studyC
    Study summary
    Very limited quality
    Design score 2/11
    Design
    Journal Article
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Not reported
    Funding
    Not reported
    Strengths
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • No control group recorded
    • Study duration not recorded

    Relevance to this claim: Ingredient-level evidence for SAMe (S-Adenosylmethionine)

    DOI: 10.1111/j.1439-0396.2012.01275.x
  • SAMe in dogs with acetaminophen-induced hepatotoxicity
    American Journal of Veterinary Research · 2004
    Save studyB
    Study summary
    Moderate quality
    Design score 6/11
    Design
    RCT
    Species
    dog
    Sample size
    Not reported
    Duration
    Not reported
    Controls / blinding
    Controlled comparison group (per recorded study design)
    Funding
    Not reported
    Strengths
    • Randomized trial design
    • Conducted in dogs
    Limitations
    • Sample size not recorded
    • Study duration not recorded

    Outcome: Reduced hepatic injury markers

Products in our catalog with SAMe (S-Adenosylmethionine) (1)

Educational information only. Not veterinary advice. Grades reflect published dog research and reviewer consensus, not marketing.