Claim evidence

Reduces mild-to-moderate OA signs in dogs

Grade BSolid canine or strong extrapolated evidenceSave claim

Ingredient: Glucosamine (HCl) · joint

Plain-language summary

Meta-analyses show a small but real benefit; effect is smaller than NSAIDs and slower to onset.

About the ingredient

What it is

Amino sugar used in cartilage matrix.

Why it's used

Included in joint-support formulas.

Also known as: Glucosamine Hydrochloride

Cited studies (5)

Canine studies

Glucosamine and chondroitin use in canines for osteoarthritis: A review
Bhathal A, Spryszak M, Louizos C, Frankel G · Open Veterinary Journal · 2017
Save studyC
Study summary
Limited quality
Design score 5/11
Design
SYSTEMATIC_REVIEW
Species
DOG
Sample size
Not reported
Duration
Not reported
Controls / blinding
Not reported
Funding
Not reported
Dose studied: 20 mg/kg/day glucosamine, 15 mg/kg/day chondroitin
Strengths
- Systematic review of multiple studies
- Conducted in dogs
Limitations
- Sample size not recorded
- No control group recorded
- Study duration not recorded
Relevance to this claim: Reviews canine glucosamine/chondroitin dosing and outcomes.
DOI: 10.4314/ovj.v7i1.6
Glucosamine and chondroitin use in canines for osteoarthritis: A review.
Bhathal A, Spryszak M, Louizos C, Frankel G · Open veterinary journal · 2017
Save studyD
Study summary
Very limited quality
Design score 2/11
Design
Journal Article; Review
Species
dog
Sample size
Not reported
Duration
Not reported
Controls / blinding
Not reported
Funding
Not reported
Strengths
- Conducted in dogs
Limitations
- Sample size not recorded
- No control group recorded
- Study duration not recorded
Relevance to this claim: Ingredient-level evidence for Glucosamine (HCl)
DOI: 10.4314/ovj.v7i1.6
The Fate of Oral Glucosamine Traced by (13)C Labeling in the Dog.
Dodge GR, Regatte RR, Noyszewski EA, Hall JO, Sharma AV, Callaway DA, Reddy R · Cartilage · 2011
Save studyC
Study summary
Very limited quality
Design score 2/11
Design
Journal Article
Species
dog
Sample size
Not reported
Duration
Not reported
Controls / blinding
Not reported
Funding
Not reported
Strengths
- Conducted in dogs
Limitations
- Sample size not recorded
- No control group recorded
- Study duration not recorded
Relevance to this claim: Ingredient-level evidence for Glucosamine (HCl)
DOI: 10.1177/1947603510391780
Randomized controlled trial evaluating glucosamine–chondroitin in canine OA
The Veterinary Journal · 2007
Save studyB
Study summary
Moderate quality
Design score 6/11
Design
RCT
Species
dog
Sample size
Not reported
Duration
Not reported
Controls / blinding
Controlled comparison group (per recorded study design)
Funding
Not reported
Strengths
- Randomized trial design
- Conducted in dogs
Limitations
- Sample size not recorded
- Study duration not recorded
Outcome: Modest improvement vs placebo over 70 days
Therapeutic Efficacy and Safety of Undenatured Type II Collagen Singly or in Combination with Glucosamine and Chondroitin in Arthritic Dogs.
D'Altilio M, Peal A, Alvey M, Simms C, Curtsinger A, Gupta RC, Canerdy TD, Goad JT, Bagchi M, Bagchi D · Toxicology mechanisms and methods · 2007
Save studyC
Study summary
Very limited quality
Design score 2/11
Design
Journal Article
Species
dog
Sample size
Not reported
Duration
Not reported
Controls / blinding
Not reported
Funding
Not reported
Strengths
- Conducted in dogs
Limitations
- Sample size not recorded
- No control group recorded
- Study duration not recorded
Relevance to this claim: Ingredient-level evidence for Glucosamine (HCl)
DOI: 10.1080/15376510600910469